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Gene id 5047
Gene Summary    Protein Summary    Gene ontology    Diseases    PubMed    

Gene Summary
Gene Symbol PAEP   Gene   UCSC   Ensembl
Aliases GD, GdA, GdF, GdS, PAEG, PEP, PP14, ZIF-1
Gene name progestagen associated endometrial protein
Alternate names glycodelin, PEG, PP14 protein (placental protein 14), alpha uterine protein, glycodelin-A, glycodelin-F, glycodelin-S, placental protein 14, pregnancy-associated endometrial alpha-2 globulin, progestagen-associated endometrial protein (placental protein 1,
Gene location 9q34.3 (135561626: 135566775)     Exons: 7     NC_000009.12
Gene summary(Entrez) This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromo
OMIM 173310

Protein Summary
Protein general information P09466  

Name: Glycodelin (GD) (Placental protein 14) (PP14) (Pregnancy associated endometrial alpha 2 globulin) (PAEG) (PEG) (Progestagen associated endometrial protein) (Progesterone associated endometrial protein) (Zona binding inhibitory factor 1) (ZIF 1)

Length: 180  Mass: 20,624

Sequence MLCLLLTLGVALVCGVPAMDIPQTKQDLELPKLAGTWHSMAMATNNISLMATLKAPLRVHITSLLPTPEDNLEIV
LHRWENNSCVEKKVLGEKTENPKKFKINYTVANEATLLDTDYDNFLFLCLQDTTTPIQSMMCQYLARVLVEDDEI
MQGFIRAFRPLPRHLWYLLDLKQMEEPCRF
Structural information
Interpro:  IPR002447  IPR012674  IPR002345  IPR022272  IPR000566  
Prosite:   PS00213

PDB:  		 4R0B
PDBsum:   4R0B
MINT:  
STRING:   ENSP00000277508
Other Databases GeneCards:  PAEP  Malacards:  PAEP

Gene ontology

Expand All | Collapse All
GO accessionTerm nameEvidence codeGo category
GO:0005515 protein binding
 IPI molecular function
GO:0005576 extracellular region
 IEA cellular component
GO:0006810 transport
 IEA biological process
GO:0006915 apoptotic process
 IDA biological process
GO:0007275 multicellular organism de
velopment
 TAS biological process
GO:0032725 positive regulation of gr
anulocyte macrophage colo
ny-stimulating factor pro
duction
 IDA biological process
GO:0036094 small molecule binding
 IEA molecular function
GO:2000667 positive regulation of in
terleukin-13 secretion
 IDA biological process
GO:2000778 positive regulation of in
terleukin-6 secretion
 IDA biological process
GO:0005515 protein binding
 IPI molecular function
GO:0005576 extracellular region
 IEA cellular component
GO:0005576 extracellular region
 IEA cellular component
GO:0006810 transport
 IEA biological process
GO:0006915 apoptotic process
 IDA biological process
GO:0007275 multicellular organism de
velopment
 TAS biological process
GO:0032725 positive regulation of gr
anulocyte macrophage colo
ny-stimulating factor pro
duction
 IDA biological process
GO:0036094 small molecule binding
 IEA molecular function
GO:2000667 positive regulation of in
terleukin-13 secretion
 IDA biological process
GO:2000778 positive regulation of in
terleukin-6 secretion
 IDA biological process
GO:0005515 protein binding
 IPI molecular function
GO:0006915 apoptotic process
 IDA biological process
GO:0007275 multicellular organism de
velopment
 TAS biological process
GO:0032725 positive regulation of gr
anulocyte macrophage colo
ny-stimulating factor pro
duction
 IDA biological process
GO:2000667 positive regulation of in
terleukin-13 secretion
 IDA biological process
GO:2000778 positive regulation of in
terleukin-6 secretion
 IDA biological process

Diseases

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Associated diseases References
Recurrent implantation failure (RIF) INFBASE: 25747132
Endometrial receptivity INFBASE: 16939926
Endometriosis INFBASE: 22563871
Female infertility INFBASE: 21292383
Implantation failure INFBASE: 18077318
Ovarian endometriosis INFBASE: 23461865
Polycystic ovary syndrome (PCOS) INFBASE: 14764802
Retarded endometrial differentiation INFBASE: 8006124
Sperm morphology MIK: 17482165
Sperm motility MIK: 7531163
Male factor infertility MIK: 9755428
Azoospermia MIK: 22182811
Azoospermia MIK: 22182811
Cryptorchidism MIK: 28606200
Male infertility MIK: 9755428
Sperm motility MIK: 7531163
Spermatogenic defects MIK: 17482165
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
9755428 Male infer
tility

Male infertility
Show abstract
7531163 Sperm moti
lity

Male infertility
Show abstract
17482165 Sperm morp
hology
42 patients
 Male infertility
Show abstract
22182811 Azoospermi
a

Male infertility Lactoferrin
Prostatic acid phosphatase
Human Zinc-Alpha-2-Glycoprotein
Prostate specific antigen
Progestagen-associated endometrial protein
Kinesin light chain 4
Kinesin light chain 4
Prolactin inducible protein
Izumo sperm-egg fusion protein 1
 Show abstract
17327269 Teratozoos
permia
19 (6 controls
, 13 cases)
 Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
28606200 Cryptorchi
dism
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
 Male infertility MeDIP-Seq
 Show abstract