|
Gene id |
4916 |
| Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
NTRK3 Gene UCSC Ensembl |
|
Aliases |
GP145-TrkC, TRKC, gp145(trkC) |
|
Gene name |
neurotrophic receptor tyrosine kinase 3 |
|
Alternate names |
NT-3 growth factor receptor, ETS related protein-neurotrophic receptor tyrosine kinase fusion protein, ETV6-NTRK3 fusion, neurotrophic tyrosine kinase, receptor, type 3, tyrosine kinase receptor C, |
|
Gene location |
15q25.3 (88256795: 87859748) Exons: 36 NC_000019.10
|
|
Gene summary(Entrez) |
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to
|
|
OMIM |
191316 |
Protein Summary
|
|
| GO accession | Term name | Evidence code | Go category |
|---|
|
|
| Pathway id | Pathway name |
|---|
| hsa04722 | Neurotrophin signaling pathway | | hsa05230 | Central carbon metabolism in cancer | | hsa04722 | Neurotrophin signaling pathway | | hsa05230 | Central carbon metabolism in cancer | |
|
| Associated diseases |
References |
| Cancer (salivary gland) | KEGG: H01508 |
| Neuroblastoma | KEGG: H00043 |
| Hypertension | GAD: 15167446 |
| Gaucher disease | GAD: 22388998 |
| Panic disorder | GAD: 12399943 |
| Mood disorders | GAD: 18347002 |
| Schizophrenia | GAD: 19344762 |
| Obsessive compulsive disorder | GAD: 18616610 |
| Autism | GAD: 19598235 |
| Depression | GAD: 18367154 |
| Attention deficit hyperactivity disorder (ADHD) | GAD: 18428117 |
| Associated with testis development and events such as seminiferous cord formation | MIK: 12021070 |
| Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
| Associated with testis development and events such as seminiferous cord formation | MIK: 12021070 |
| Cryptorchidism | MIK: 28606200 |
| Teratozoospermia | MIK: 17327269 |
| Unexplained infertility | MIK: 25753583 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 12021070 |
Associated
with test
is develop
ment and e
vents such
as semini
ferous cor
d formatio
n
|
|
|
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 21674046 |
Aberrant C
pGs in Low
Motility
Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
| 28606200 |
Cryptorchi
dism
|
|
|
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
|
Male infertility |
MeDIP-Seq
|
Show abstract |
| 25753583 |
Unexplaine
d infertil
ity
|
|
|
46 (17 fertile
men, 29 male pa
tients)
|
Male infertility |
Microarray
|
Show abstract |
|