• Gene id: 4898

Gene Summary

• Gene Symbol: NRDC   Gene   UCSC   Ensembl
• Aliases: NRD1, hNRD1, hNRD2
• Gene name: nardilysin convertase
• Alternate names: nardilysin, NRD convertase, nardilysin (N-arginine dibasic convertase),
• Gene location: 1p32.3 (51878936: 51789191)     Exons: 34     NC_000001.11
• Gene summary(Entrez): This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and
• OMIM: 605764

Protein Summary

• Protein general information: O43847  
  • Name: Nardilysin (EC 3.4.24.61) (N arginine dibasic convertase) (NRD convertase) (NRD C) (Nardilysin convertase)
  • Length: 1151  
  • Mass: 131701
  • Tissue specificity: Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues.
• Sequence:

  MLRRVTVAAVCATRRKLCEAGRELAALWGIETRGRCEDSAAARPFPILAMPGRNKAKSTCSCPDLQPNGQDLGEN
  SRVARLGADESEEEGRRGSLSNAGDPEIVKSPSDPKQYRYIKLQNGLQALLISDLSNMEGKTGNTTDDEEEEEVE
  EEEEDDDEDSGAEIEDDDEEGFDDEDEFDDEHDDDLDTEDNELEELEERAEARKKTTEKQSAAALCVGVGSFADP
  DDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMI
  RDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPRKNNIDTHARLREFWMRYYS
  SHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPRPNFGHLTDPFDTPAFNKLYRVVPIRKIHALTITWALPPQQ
  QHYRVKPLHYISWLVGHEGKGSILSFLRKKCWALALFGGNGETGFEQNSTYSVFSISITLTDEGYEHFYEVAYTV
  FQYLKMLQKLGPEKRIFEEIRKIEDNEFHYQEQTDPVEYVENMCENMQLYPLQDILTGDQLLFEYKPEVIGEALN
  QLVPQKANLVLLSGANEGKCDLKEKWFGTQYSIEDIENSWAELWNSNFELNPDLHLPAENKYIATDFTLKAFDCP
  ETEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEY
  KLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFNSTPAVFTMITEQLKKTYFNILIKPETLAKDVRLLILEYAR
  WSMIDKYQALMDGLSLESLLSFVKEFKSQLFVEGLVQGNVTSTESMDFLKYVVDKLNFKPLEQEMPVQFQVVELP
  SGHHLCKVKALNKGDANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGF
  SVTVGTQATKYNSEVVDKKIEEFLSSFEEKIENLTEEAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTQQYLF
  DRLAHEIEALKSFSKSDLVNWFKAHRGPGSKMLSVHVVGYGKYELEEDGTPSSEDSNSSCEVMQLTYLPTSPLLA
  DCIIPITDIRAFTTTLNLLPYHKIVK

• Structural information:
  • Interpro: IPR011249  IPR011765  IPR001431  IPR007863  IPR032632  
  • Prosite: PS00143
  • STRING: ENSP00000346890
• Other Databases: GeneCards:  NRDC  Malacards:  NRDC

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0051603	proteolysis involved in cellular protein catabolic process	IBA	biological process
GO:0005739	mitochondrion	IBA	cellular component
GO:0043171	peptide catabolic process	IBA	biological process
GO:0006508	proteolysis	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0003824	catalytic activity	IEA	molecular function
GO:0004222	metalloendopeptidase activity	IEA	molecular function
GO:0008233	peptidase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0008237	metallopeptidase activity	IEA	molecular function
GO:0005739	mitochondrion	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0051044	positive regulation of membrane protein ectodomain proteolysis	IDA	biological process
GO:0052548	regulation of endopeptidase activity	IDA	biological process
GO:0120163	negative regulation of cold-induced thermogenesis	ISS	biological process
GO:0004222	metalloendopeptidase activity	NAS	molecular function
GO:0009986	cell surface	TAS	cellular component
GO:0048408	epidermal growth factor binding	TAS	molecular function
GO:0005829	cytosol	TAS	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq