• Gene id: 460

Gene Summary

• Gene Symbol: ASTN1   Gene   UCSC   Ensembl
• Aliases: ASTN
• Gene name: astrotactin 1
• Alternate names: astrotactin-1,
• Gene location: 1q25.2 (177164903: 176855116)     Exons: 26     NC_000001.11
• Gene summary(Entrez): Astrotactin is a neuronal adhesion molecule required for glial-guided migration of young postmitotic neuroblasts in cortical regions of developing brain, including cerebrum, hippocampus, cerebellum, and olfactory bulb (Fink et al., 1995).[supplied by OMIM
• OMIM: 611888

Protein Summary

• Protein general information: O14525  
  • Name: Astrotactin 1
  • Length: 1302  
  • Mass: 144913
• Sequence:

  MALAGLCALLACCWGPAAVLATAAGDVDPSKELECKLKSITVSALPFLRENDLSIMHSPSASEPKLLFSVRNDFP
  GEMVVVDDLENTELPYFVLEISGNTEDIPLVRWRQQWLENGTLLFHIHHQDGAPSLPGQDPTEEPQHESAEEELR
  ILHISVMGGMIALLLSILCLVMILYTRRRWCKRRRVPQPQKSASAEAANEIHYIPSVLIGGHGRESLRNARVQGH
  NSSGTLSIRETPILDGYEYDITDLRHHLQRECMNGGEDFASQVTRTLDSLQGCNEKSGMDLTPGSDNAKLSLMNK
  YKDNIIATSPVDSNHQQATLLSHTSSSQRKRINNKARAGSAFLNPEGDSGTEAENDPQLTFYTDPSRSRRRSRVG
  SPRSPVNKTTLTLISITSCVIGLVCSSHVNCPLVVKITLHVPEHLIADGSRFILLEGSQLDASDWLNPAQVVLFS
  QQNSSGPWAMDLCARRLLDPCEHQCDPETGRREHRAAGECLCYEGYMKDPVHKHLCIRNEWGTNQGPWPYTIFQR
  GFDLVLGEQPSDKIFRFTYTLGEGMWLPLSKSFVIPPAELAINPSAKCKTDMTVMEDAVEVREELMTSSSFDSLE
  VLLDSFGPVRDCSKDNGGCSKNFRCISDRKLDSTGCVCPSGLSPMKDSSGCYDRHIGVDCSDGFNGGCEQLCLQQ
  MAPFPDDPTLYNILMFCGCIEDYKLGVDGRSCQLITETCPEGSDCGESRELPMNQTLFGEMFFGYNNHSKEVAAG
  QVLKGTFRQNNFARGLDQQLPDGLVVATVPLENQCLEEISEPTPDPDFLTGMVNFSEVSGYPVLQHWKVRSVMYH
  IKLNQVAISQALSNALHSLDGATSRADFVALLDQFGNHYIQEAIYGFEESCSIWYPNKQVQRRLWLEYEDISKGN
  SPSDESEERERDPKVLTFPEYITSLSDSGTKHMAAGVRMECHSKGRCPSSCPLCHVTSSPDTPAEPVLLEVTKAA
  PIYELVTNNQTQRLLQEATMSSLWCSGTGDVIEDWCRCDSTAFGADGLPTCAPLPQPVLRLSTVHEPSSTLVVLE
  WEHSEPPIGVQIVDYLLRQEKVTDRMDHSKVETETVLSFVDDIISGAKSPCAMPSQVPDKQLTTISLIIRCLEPD
  TIYMFTLWGVDNTGRRSRPSDVIVKTPCPVVDDVKAQEIADKIYNLFNGYTSGKEQQTAYNTLLDLGSPTLHRVL
  YHYNQHYESFGEFTWRCEDELGPRKAGLILSQLGDLSSWCNGLLQEPKISLRRSSLKYLGCRYSEIKPYGLDWAE
  LSRDLRKTCEEQTLSIPYNDYGDSKEI

• Structural information:
  • Protein Domains: (459..50-)
    (/note="EGF-like-1)
    (608..65-)
    (/note="EGF-like-2)
    (656..70-)
    (/note="EGF-like-3)
    (1030..114-)
    (/note="Fibronectin-type-III")
  • Interpro: IPR040685  IPR026995  IPR000742  IPR003961  IPR036116   IPR020864  
  • CDD: cd00063
  • STRING: ENSP00000354536
• Other Databases: GeneCards:  ASTN1  Malacards:  ASTN1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007158	neuron cell-cell adhesion	IBA	biological process
GO:0005768	endosome	IBA	cellular component
GO:0001764	neuron migration	IBA	biological process
GO:0016021	integral component of membrane	IBA	cellular component
GO:0031410	cytoplasmic vesicle	IEA	cellular component
GO:0005768	endosome	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0007155	cell adhesion	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0001764	neuron migration	IEA	biological process
GO:0005768	endosome	IEA	cellular component
GO:0007158	neuron cell-cell adhesion	IEA	biological process
GO:0007626	locomotory behavior	IEA	biological process
GO:0016477	cell migration	IEA	biological process
GO:0098609	cell-cell adhesion	IEA	biological process
GO:0009897	external side of plasma membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0043204	perikaryon	IEA	cellular component
GO:0030136	clathrin-coated vesicle	IEA	cellular component
GO:0005768	endosome	IEA	cellular component
GO:0005575	cellular_component	ND	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq