• Gene id: 400966

Gene Summary

• Gene Symbol: RGPD1   Gene   UCSC   Ensembl
• Aliases: RGP1, RGPD2, RanBP2L2, ranBP2L6
• Gene name: RANBP2 like and GRIP domain containing 1
• Alternate names: RANBP2-like and GRIP domain-containing protein 1, RANBP2-like and GRIP domain-containing protein 1/2, ran-binding protein 2-like 2/6, ran-binding protein 2-like 6, ranBP2-like 2/6, ranBP2-like 6,
• Gene location: 2p11.2 (86913576: 87013975)     Exons: 30     NC_000002.12

Protein Summary

• Protein general information: P0DJD0  
  • Name: RANBP2 like and GRIP domain containing protein 1 (Ran binding protein 2 like 6) (RanBP2 like 6) (RanBP2L6)
  • Length: 1748  
  • Mass: 196662
• Sequence:

  MNVMGFNTDRLAWTRNKLRGFYFAKLYYEAKEYDLAKKYVCTYLSVQERDPRAHRFLGLLYELEENTEKAVECYR
  RSLELNPPQKDLVLKIAELLCKNDVTDGRAKYWVERAAKLFPGSPAIYKLKEHLLDCEGEDGWNKLFDWIQSELY
  VRPDDVHMNIRLVELYRSNKRLKDAVARCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTD
  LLLAYANLMLLTLSTRDVQESRELLESFDSALQSAKSSLGGNDELSATFLEMKGHFYMHAGSLLLKMGQHGNNVQ
  WQALSELAALCYVIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLNLSRGKQDFLKEVVETFANKSGQS
  VLYNALFSSQSSKDTSFLGSDDIGNIDVQEPELEDLARYDVGAIQAHNGSLQHLTWLGLQWNSLPALPGIRKWLK
  QLFHHLPQETSRLETNAPESICILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKRLCTERQKSWWD
  AVCTLIHRKAVPGNSAELRLVVQHEINTLRAQEKHGLQPALLVHWAKCLQKMGRGLNSSYDQQEYIGRSVHYWKK
  VLPLLKIIKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAVHGNIEDAVTAFESIKSVVSYWNLA
  LIFHRKAEDIENDAVFPEEQEECKNYLRKTRDYLIKIIDDSDSNLSVVKKLPVPLESVKEMLKSVMQELEDYSEG
  GPLYKNGSLRNADSEIKHSTPSPTKYSLSPSKSYKYSPKTPPRWAEDQNSLRKMICQEVKAITKLNSSKSASRHR
  WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGSSNTEFKSTKEGFSI
  AVSADGFKFGISEPGNQEKKSEKPLENDTGFQAQDISGQKNGRGVIFGQTSSTFTFADVAKSTSGEGFQFGKKDP
  NFKGFSGAGEKLFSSQCGKMANKANTSGDFEKDDDACKTEDSDDIHFEPVVQMPEKVELVTGEEGEKVLYSQGVK
  LFRFDAEISQWKERGLGNLKILKNEVNGKPRMLMRRDQVLKVCANHWITTTMNLKPLSGSDRAWMWLASDFSDGD
  AKLERLAAQFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGLKDFKTFLTNDQTKV
  TEEENKGSGTGAAGASDTTIKPNPENTGPTLEWDNYDLREDALDDNVSSSSVHDSPLASSPVRKNIFRFDESTTG
  FNFSFKSALSLSKSPAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAELYR
  YDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMSLQNMKGTERVWVWTACDFADGERKV
  EHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPRESPCGKIAVAVLEETTRERTDVIQGDDVADA
  ASEVEVSSTSETTTKAVVSPPKFVFGSESVKRIFSSEKSNPFAFGNSSATGSLFGFSFNAPLKSNDSETSSVAQS
  GSESKVEPKKCELSKNSDIEQSSDSKVKNLSASFPMEESSINYTFKTPEKEPPLWHAEFTKEELVQKLSSTTKSA
  DQLNGLLRETEATSAVLMEQIKLLKSEIRRLERNQEESAANVEHLKNVLLQFIFLKPGSERESLLPVINTMLQLS
  PEEKGKLAAVAQGLQETSIPKKK

• Structural information:
  • Protein Domains: (1021..115-)
    (/note="RanBD1-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00164-)
    (1318..145-)
    (/note="RanBD1-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00164-)
    (1685..173-)
    (/note="GRIP-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU-)
  • Interpro: IPR032023  IPR000237  IPR011993  IPR000156  IPR013026   IPR011990  IPR019734  
  • Prosite: PS50913 PS50196 PS50005 PS50293
  • STRING: ENSP00000453170
• Other Databases: GeneCards:  RGPD1  Malacards:  RGPD1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005643	nuclear pore	IBA	cellular component
GO:0006607	NLS-bearing protein import into nucleus	IBA	biological process
GO:0005096	GTPase activator activity	IBA	contributes to
GO:0005634	nucleus	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0008536	Ran GTPase binding	IBA	molecular function
GO:0046907	intracellular transport	IEA	biological process
GO:0043547	positive regulation of GTPase activity	IEA	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq