• Gene id: 3977

Gene Summary

• Gene Symbol: LIFR   Gene   UCSC   Ensembl
• Aliases: CD118, LIF-R, SJS2, STWS, SWS
• Gene name: LIF receptor subunit alpha
• Alternate names: leukemia inhibitory factor receptor, CD118 antigen, LIF receptor, LIF receptor alpha, leukemia inhibitory factor receptor alpha,
• Gene location: 5p13.1 (38606289: 38474667)     Exons: 1     NC_000005.10
• Gene summary(Entrez): This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional c
• OMIM: 151443

Protein Summary

• Protein general information: P42702  
  • Name: Leukemia inhibitory factor receptor (LIF receptor) (LIF R) (CD antigen CD118)
  • Length: 1097  
  • Mass: 123743
• Sequence:

  MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNLQVWNCSWKAPSGTGR
  GTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGSSTSKFTLNEQNVSLIPDTPEILNLSADFST
  STLYLKWNDRGSVFPHRSNVIWEIKVLRKESMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYID
  NLHFSGLEEWSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIK
  IRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESF
  SGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVK
  LSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNK
  KQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDK
  NDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWR
  KVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVE
  ELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSM
  YVVTKENSVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEM
  NPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPNPAADEAGGTAQVIYI
  DVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEEDLDKTAGYRPQANVNTWNLVSPDSPRSIDS
  NSEIVSFGSPCSINSRQFLIPPKDEDSPKSNGGGWSFTNFFQNKPND

• Structural information:
  • Protein Domains: (49..13-)
    1 (/note="Fibronectin-type-III)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00316-)
    (335..43-)
    2 (/note="Fibronectin-type-III)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00316-)
    (435..53-)
    3 (/note="Fibronectin-type-III)
    (/ev-)
  • Interpro: IPR003961  IPR036116  IPR003529  IPR013783  IPR040817   IPR040901  
  • Prosite: PS50853 PS01353
  • CDD: cd00063
  • PDB: 3E0G
  • PDBsum: 3E0G
  • DIP: 5770
  • STRING: ENSP00000263409
• Other Databases: GeneCards:  LIFR  Malacards:  LIFR

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004923	leukemia inhibitory factor receptor activity	IBA	molecular function
GO:0008284	positive regulation of cell population proliferation	IBA	biological process
GO:0019221	cytokine-mediated signaling pathway	IBA	biological process
GO:0019955	cytokine binding	IBA	molecular function
GO:0043235	receptor complex	IBA	cellular component
GO:0004896	cytokine receptor activity	IBA	molecular function
GO:0004924	oncostatin-M receptor activity	IBA	contributes to
GO:0005127	ciliary neurotrophic factor receptor binding	IBA	molecular function
GO:0009897	external side of plasma membrane	IBA	cellular component
GO:0004896	cytokine receptor activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0004923	leukemia inhibitory factor receptor activity	TAS	molecular function
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0007166	cell surface receptor signaling pathway	TAS	biological process
GO:0019221	cytokine-mediated signaling pathway	IDA	biological process
GO:0008284	positive regulation of cell population proliferation	IDA	biological process
GO:0004923	leukemia inhibitory factor receptor activity	IDA	molecular function
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0001959	regulation of cytokine-mediated signaling pathway	TAS	biological process
GO:0019221	cytokine-mediated signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0008284	positive regulation of cell population proliferation	IEA	biological process
GO:0043235	receptor complex	IDA	cellular component
GO:0043235	receptor complex	IDA	cellular component
GO:0004923	leukemia inhibitory factor receptor activity	IDA	contributes to
GO:0004923	leukemia inhibitory factor receptor activity	IDA	contributes to
GO:0038165	oncostatin-M-mediated signaling pathway	IMP	biological process
GO:0004897	ciliary neurotrophic factor receptor activity	IDA	contributes to
GO:0004924	oncostatin-M receptor activity	IDA	contributes to
GO:0005127	ciliary neurotrophic factor receptor binding	IPI	molecular function
GO:0019838	growth factor binding	IPI	molecular function
GO:0008284	positive regulation of cell population proliferation	IDA	biological process
GO:0034097	response to cytokine	IDA	biological process
GO:0048861	leukemia inhibitory factor signaling pathway	IDA	biological process
GO:0048861	leukemia inhibitory factor signaling pathway	IDA	biological process
GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	IDA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04060	Cytokine-cytokine receptor interaction
hsa04630	JAK-STAT signaling pathway
hsa04550	Signaling pathways regulating pluripotency of stem cells

Diseases

Associated diseases	References
Stuve-Wiedemann syndrome	KEGG:H00462
Stuve-Wiedemann syndrome	KEGG:H00462
Osteochondrodysplasia	PMID:14740318
Asthenoozoospermia	MIK: 32167074
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
32167074	Asthenoozoospermia			12 (6controls, 6 cases)	Male infertility	Microarray