• Gene id: 391002

Gene Summary

• Gene Symbol: PRAMEF8   Gene   UCSC   Ensembl
• Aliases: PRAMEF24
• Gene name: PRAME family member 8
• Alternate names: PRAME family member 8, putative PRAME family member 24,
• Gene location: 1p36.21 (13285136: 13281222)     Exons: 4     NC_000001.11

Protein Summary

• Protein general information: Q5VWM4  
  • Name: PRAME family member 8
  • Length: 474  
  • Mass: 53655
• Sequence:

  MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWPFTRLPLGSLMKSPHL
  ESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGATASFPEALSQKQTADNCPGTGRQQPFMVFID
  LCLKNRTLDECLTHLLEWGKQRKGLLHVCCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPY
  LGQMRNLRKLVLFNIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVVMT
  DCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDCGIMDSQLSAILPVLSRC
  SQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPLESYDTQGALCWGRFAELGAELMNTLRDLRQPKIIV
  FCTVPCPRCGIRASYDLEPSHCLC

• Structural information:
  • Interpro: IPR032675  IPR026271  
  • STRING: ENSP00000349931
• Other Databases: GeneCards:  PRAMEF8  Malacards:  PRAMEF8

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IBA	cellular component
GO:0008284	positive regulation of cell population proliferation	IEA	biological process
GO:0043066	negative regulation of apoptotic process	IEA	biological process
GO:0045596	negative regulation of cell differentiation	IEA	biological process
GO:0045892	negative regulation of transcription, DNA-templated	IEA	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)