• Gene id: 389289

Gene Summary

• Gene Symbol: ANXA2R   Gene   UCSC   Ensembl
• Aliases: AX2R, AXIIR, C5orf39
• Gene name: annexin A2 receptor
• Alternate names: annexin-2 receptor, annexin II receptor,
• Gene location: 5p12 (88913404: 88898682)     Exons: 12     NC_000015.10
• OMIM: 611296

Protein Summary

• Protein general information: Q3ZCQ2  
  • Name: Annexin 2 receptor (Annexin II receptor) (AXIIR)
  • Length: 193  
  • Mass: 21682
  • Tissue specificity: Widely expressed. Highly expressed in lymphocytes. Expressed in both resting CD4(+) and CD8(+) T-cells. {ECO
• Sequence:

  MEQHFLGCVKRAWDSAEVAPEPQPPPIVSSEDRGPWPLPLYPVLGEYSLDSCDLGLLSSPCWRLPGVYWQNGLSP
  GVQSTLEPSTAKPTEFSWPGTQKQQEAPVEEVGQAEEPDRLRLQQLPWSSPLHPWDRQQDTEVCDSGCLLERRHP
  PALQPWRHLPGFSDCLEWILRVGFAAFSVLWACCSRICGAKQP

• Structural information:
  • Interpro: IPR031449  
  • STRING: ENSP00000315915
• Other Databases: GeneCards:  ANXA2R  Malacards:  ANXA2R

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0038023	signaling receptor activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray