• Gene id: 388121

Gene Summary

• Gene Symbol: TNFAIP8L3   Gene   UCSC   Ensembl
• Aliases: TIPE3
• Gene name: TNF alpha induced protein 8 like 3
• Alternate names: tumor necrosis factor alpha-induced protein 8-like protein 3, TNF alpha-induced protein 8-like protein 3, TNFAIP8-like protein 3, tumor necrosis factor, alpha induced protein 8 like 3,
• Gene location: 15q21.2 (51105275: 51056600)     Exons: 3     NC_000015.10
• OMIM: 617327

Protein Summary

• Protein general information: Q5GJ75  
  • Name: Tumor necrosis factor alpha induced protein 8 like protein 3 (TNF alpha induced protein 8 like protein 3) (TNFAIP8 like protein 3)
  • Length: 292  
  • Mass: 32659
  • Tissue specificity: Widely expressed (at protein level) (PubMed
• Sequence:

  MGKPRQNPSTLVSTLCEAEPKGKLWVNGYAGTQGTRDATLQTRLIPLSFHLQRGKGLAAPLSALSAPRLPERPAD
  GRVAVDAQPAARSMDSDSGEQSEGEPVTAAGPDVFSSKSLALQAQKKILSKIASKTVANMLIDDTSSEIFDELYK
  VTKEHTHNKKEAHKIMKDLIKVAIKIGILYRNNQFSQEELVIVEKFRKKLNQTAMTIVSFYEVEYTFDRNVLSNL
  LHECKDLVHELVQRHLTPRTHGRINHVFNHFADVEFLSTLYSLDGDCRPNLKRICEGINKLLDEKVL

• Structural information:
  • Interpro: IPR008477  IPR038355  
  • PDB: 4Q9V
  • PDBsum: 4Q9V
  • STRING: ENSP00000328016
• Other Databases: GeneCards:  TNFAIP8L3  Malacards:  TNFAIP8L3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IBA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0008526	phosphatidylinositol transfer activity	ISS	molecular function
GO:0048017	inositol lipid-mediated signaling	ISS	biological process
GO:0019216	regulation of lipid metabolic process	ISS	biological process
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	ISS	biological process
GO:0005886	plasma membrane	ISS	cellular component
GO:0035091	phosphatidylinositol binding	ISS	molecular function
GO:0015914	phospholipid transport	ISS	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISS	biological process
GO:0051897	positive regulation of protein kinase B signaling	ISS	biological process
GO:0042981	regulation of apoptotic process	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0006869	lipid transport	IEA	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0006644	phospholipid metabolic process	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0008526	phosphatidylinositol transfer activity	IEA	molecular function
GO:0019216	regulation of lipid metabolic process	IEA	biological process
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	IEA	biological process
GO:0048017	inositol lipid-mediated signaling	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0015914	phospholipid transport	IEA	biological process
GO:0035091	phosphatidylinositol binding	IEA	molecular function
GO:0051897	positive regulation of protein kinase B signaling	IEA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0120009	intermembrane lipid transfer	IEA	biological process
GO:0120009	intermembrane lipid transfer	IEA	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq