• Gene id: 378108

Gene Summary

• Gene Symbol: TRIM74   Gene   UCSC   Ensembl
• Aliases: TRIM50C
• Gene name: tripartite motif containing 74
• Alternate names: tripartite motif-containing protein 74, tripartite motif-containing 50C, tripartite motif-containing protein 50C,
• Gene location: 7q11.23 (4087343: 4050332)     Exons: 10     NC_000006.12
• OMIM: 612550

Protein Summary

• Protein general information: Q86UV6  
  • Name: Tripartite motif containing protein 74 (Tripartite motif containing protein 50C)
  • Length: 250  
  • Mass: 28547
• Sequence:

  MAWQVSLLELEDWLQCPICLEVFKESLMLQCGHSYCKGCLVSLSYHLDTKVRCPMCWQVVDGSSSLPNVSLAWVI
  EALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHHPVTPVSTVCSRMKEELAALFSELKQEQKKV
  DELIAKLVKNRTRIVNESDVFSWVIRREFQELRHPVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQA
  ECVLEQFGNEDHHEFIWKFHSMASR

• Structural information:
  • Interpro: IPR027370  IPR000315  IPR001841  IPR013083  IPR017907  
  • Prosite: PS50119 PS00518 PS50089
  • CDD: cd00021
  • STRING: ENSP00000285805
• Other Databases: GeneCards:  TRIM74  Malacards:  TRIM74

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IBA	cellular component
GO:0016567	protein ubiquitination	IBA	biological process
GO:0061630	ubiquitin protein ligase activity	IBA	molecular function
GO:0008270	zinc ion binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005829	cytosol	IDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881