• Gene id: 375757

Gene Summary

• Gene Symbol: SWI5   Gene   UCSC   Ensembl
• Aliases: C9orf119, SAE3
• Gene name: SWI5 homologous recombination repair protein
• Alternate names: DNA repair protein SWI5 homolog, HBV DNAPTP1-transactivated protein A, SWI5 recombination repair homolog, protein SAE3 homolog,
• Gene location: 9q34.11 (128275363: 128288989)     Exons: 7     NC_000009.12
• OMIM: 616528

Protein Summary

• Protein general information: Q1ZZU3  
  • Name: DNA repair protein SWI5 homolog (HBV DNAPTP1 transactivated protein A) (Protein SAE3 homolog)
  • Length: 235  
  • Mass: 26739
• Sequence:

  MQRRGQRDLWRHNKSCARNRCPRPPRERGGAGFPWVRAQLSVRQFTLRVRVPGPVHLRGRSPTPALDPLAPLNPL
  IRGPRTPGLRRWIQSLALLLPNCSSSRIPTVPRPHSGLWVQSDFPLGFLSRTEPRLTRSCRGAFRSPRPLPKSGQ
  ADGTSEESLHLDIQKLKEKRDMLDKEISQFVSEGYSVDELEDHITQLHEYNDIKDVGQMLMGKLAVIRGVTTKEL
  YPEFGLDMND

• Structural information:
  • Interpro: IPR010760  
  • STRING: ENSP00000316609
• Other Databases: GeneCards:  SWI5  Malacards:  SWI5

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0032798	Swi5-Sfr1 complex	IBA	cellular component
GO:0000730	DNA recombinase assembly	IBA	biological process
GO:0071479	cellular response to ionizing radiation	IBA	biological process
GO:0032798	Swi5-Sfr1 complex	IDA	cellular component
GO:0071479	cellular response to ionizing radiation	IDA	biological process
GO:0005634	nucleus	ISS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0000724	double-strand break repair via homologous recombination	IMP	biological process
GO:0006281	DNA repair	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0006974	cellular response to DNA damage stimulus	IEA	biological process
GO:0005634	nucleus	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)