• Gene id: 342931

Gene Summary

• Gene Symbol: RFPL4A   Gene   UCSC   Ensembl
• Aliases: RFPL4, RNF210
• Gene name: ret finger protein like 4A
• Alternate names: ret finger protein-like 4A, RING finger protein 210, ret finger protein-like 4,
• Gene location: 19q13.42 (55757297: 55763420)     Exons: 4     NC_000019.10

Protein Summary

• Protein general information: A6NLU0  
  • Name: Ret finger protein like 4A (RING finger protein 210)
  • Length: 287  
  • Mass: 32238
• Sequence:

  MAEHFKQIIRCPVCLKDLEEAVQLKCGYACCLQCLNSLQKEPDGEGLLCRFCSVVSQKDDIKPKYKLRALVSIIK
  ELEPKLKSVLTMNPRMRKFQVDMTFDVDTANNYLIISEDLRSFRSGDLSQNRKEQAERFDTALCVLGTPRFTSGR
  HYWEVDVGTSQVWDVGVCKESVNRQGKIVLSSEHGFLTVGCREGKVFAASTVPMTPLWVSPQLHRVGIFLDVGMR
  SIAFYNVSDGCHIYTFIEIPVCEPWRPFFAHKRGSQDDQSILSICSVINPSAASAPVSSEGK

• Structural information:
  • Protein Domains: (78..27-)
    (/note="B30.2/SPRY-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00548"-)
  • Interpro: IPR001870  IPR003879  IPR013320  IPR006574  IPR022723   IPR038908  IPR037960  IPR003877  IPR001841  IPR013083  
  • Prosite: PS50188 PS50089
  • CDD: cd15821
  • PDB: 2FBE
  • PDBsum: 2FBE
  • STRING: ENSP00000392936
• Other Databases: GeneCards:  RFPL4A  Malacards:  RFPL4A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004842	ubiquitin-protein transferase activity	IBA	molecular function
GO:0005654	nucleoplasm	IBA	cellular component
GO:0045893	positive regulation of transcription, DNA-templated	IBA	biological process
GO:0000785	chromatin	IBA	cellular component
GO:0046872	metal ion binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0016567	protein ubiquitination	IEA	biological process

Diseases

Associated diseases	References
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray