• Gene id: 340562

Gene Summary

• Gene Symbol: SATL1   Gene   UCSC   Ensembl
• Gene name: spermidine/spermine N1-acetyl transferase like 1
• Alternate names: spermidine/spermine N(1)-acetyltransferase-like protein 1,
• Gene location: Xq21.1 (85243778: 85092283)     Exons: 12     NC_000023.11

Protein Summary

• Protein general information: Q86VE3  
  • Name: Spermidine/spermine N(1) acetyltransferase like protein 1 (EC 2.3.1. )
  • Length: 695  
  • Mass: 75812
• Sequence:

  MNQSGTNQSSLSDSNQAGINQPSTNSLGMNQMDMNQGSASLYEMNQVDMKQPSMSQAGMRQSGTNLPDINQPDMK
  QPDTWQLGRSQPGMLQQELSQLVLSKAGISQPDPSQPGPSQSGPSQSRMRQIGTNQSGMSQPVMQQLDSQSGGSQ
  PSMRQVGTSQLGTSQIGMSQPGTWQTGLSQPVLRQPNMSPPGMWQPGVQQPGISQQVPSHPDMSQPGMSQQVPSQ
  PGIRQPDTSQSCKNQTDMSQPDANQSSLSDSNQTGIIQPSPSLLGMNQMDMNQWSASLYEMNQVDMKQPSMSQAG
  MRQSGTNLPDINQPGMKQPGTWQLGRSQPGMWPQSLSELVLSEASISQPGPPQRAPSQSGPRQSSTSQAGTNQSG
  ISQPVMWQLDMRQSGGSQPSMRQVGTSQSGTSQIGMSQPGTWQTGLSQPVPRQPNKSPPGMWQRGMWQPGMSQQV
  PSQLGMRQPGTSQSSKNQTGMSHPGRGQPGIWEPGPSQPGLSQQDLNQLVLSQPGLSQPGRSQPSVSQMGMRQTS
  MDYFQIRHAEAGDCPEILRLIKELAACENMLDAMELTAADLLRDGFGDNPLFYCLIAEVNDQQKPSGKLTVGFAM
  YYFTYDSWTGKVLYLEDFYVTQAYQGLGIGAEMLKRLSQIAITTQCNCMHFLVVIWNQASINYYTSRGALDLSSE
  EGWHLFRFNREELLDMAWEE

• Structural information:
  • Protein Domains: (529..69-)
    (/note="N-acetyltransferase-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00532"-)
  • Interpro: IPR016181  IPR000182  IPR039533  
  • Prosite: PS51186
  • STRING: ENSP00000425421
• Other Databases: GeneCards:  SATL1  Malacards:  SATL1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004145	diamine N-acetyltransferase activity	IBA	molecular function
GO:0005829	cytosol	IBA	cellular component
GO:0008080	N-acetyltransferase activity	IBA	molecular function
GO:0019809	spermidine binding	IBA	molecular function
GO:0032918	spermidine acetylation	IBA	biological process
GO:0008080	N-acetyltransferase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0016746	transferase activity, transferring acyl groups	IEA	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray