• Gene id: 340152

Gene Summary

• Gene Symbol: ZC3H12D   Gene   UCSC   Ensembl
• Aliases: C6orf95, MCPIP4, TFL, dJ281H8.1, p34
• Gene name: zinc finger CCCH-type containing 12D
• Alternate names: probable ribonuclease ZC3H12D, Zinc finger CCCH domain-containing protein 12D, transformed follicular lymphoma, tumor suppressor TFL,
• Gene location: 6q25.1 (149485013: 149446794)     Exons: 6     NC_000006.12

Protein Summary

• Protein general information: A2A288  
  • Name: Probable ribonuclease ZC3H12D (EC 3.1. . ) (MCP induced protein 4) (Transformed follicular lymphoma) (Zinc finger CCCH domain containing protein 12D) (p34)
  • Length: 527  
  • Mass: 58078
  • Tissue specificity: Expressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines. {ECO
• Sequence:

  MEHPSKMEFFQKLGYDREDVLRVLGKLGEGALVNDVLQELIRTGSRPGALEHPAAPRLVPRGSCGVPDSAQRGPG
  TALEEDFRTLASSLRPIVIDGSNVAMSHGNKETFSCRGIKLAVDWFRDRGHTYIKVFVPSWRKDPPRADTPIREQ
  HVLAELERQAVLVYTPSRKVHGKRLVCYDDRYIVKVAYEQDGVIVSNDNYRDLQSENPEWKWFIEQRLLMFSFVN
  DRFMPPDDPLGRHGPSLSNFLSRKPKPPEPSWQHCPYGKKCTYGIKCKFYHPERPHHAQLAVADELRAKTGARPG
  AGAEEQRPPRAPGGSAGARAAPREPFAHSLPPARGSPDLAALRGSFSRLAFSDDLGPLGPPLPVPACSLTPRLGG
  PDWVSAGGRVPGPLSLPSPESQFSPGDLPPPPGLQLQPRGEHRPRDLHGDLLSPRRPPDDPWARPPRSDRFPGRS
  VWAEPAWGDGATGGLSVYATEDDEGDARARARIALYSVFPRDQVDRVMAAFPELSDLARLILLVQRCQSAGAPLG
  KP

• Structural information:
  • Interpro: IPR040546  IPR021869  IPR000571  
  • Prosite: PS50103
  • STRING: ENSP00000386616
• Other Databases: GeneCards:  ZC3H12D  Malacards:  ZC3H12D

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003729	mRNA binding	IBA	molecular function
GO:0004521	endoribonuclease activity	IBA	molecular function
GO:0036464	cytoplasmic ribonucleoprotein granule	IBA	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0006402	mRNA catabolic process	IBA	biological process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	IBA	biological process
GO:0000932	P-body	IDA	cellular component
GO:0061158	3'-UTR-mediated mRNA destabilization	ISS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0004518	nuclease activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0004519	endonuclease activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0000932	P-body	IDA	cellular component
GO:0000932	P-body	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0036464	cytoplasmic ribonucleoprotein granule	IDA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq