• Gene id: 339896

Gene Summary

• Gene Symbol: GADL1   Gene   UCSC   Ensembl
• Aliases: ADC, CSADC, HuADC, HuCSADC
• Gene name: glutamate decarboxylase like 1
• Alternate names: acidic amino acid decarboxylase GADL1, aspartate 1-decarboxylase, cysteine sulfinic acid decarboxylase, glutamate decarboxylase-like protein 1,
• Gene location: 3p24.1-p23 (30894660: 30726008)     Exons: 17     NC_000003.12
• OMIM: 615601

Protein Summary

• Protein general information: Q6ZQY3  
  • Name: Acidic amino acid decarboxylase GADL1 (Aspartate 1 decarboxylase) (ADC) (HuADC) (EC 4.1.1.11) (Cysteine sulfinic acid decarboxylase) (CSADC) (HuCSADC) (EC 4.1.1.29) (Glutamate decarboxylase like protein 1)
  • Length: 521  
  • Mass: 59246
  • Tissue specificity: Expressed very weakly in neurons and not detected in astrocytes, brain or liver. {ECO
• Sequence:

  MSSDSDRQCPVDGDIDQQEMIPSKKNAVLVDGVVLNGPTTDAKAGEKFVEEACRLIMEEVVLKATDVNEKVCEWR
  PPEQLKQLLDLEMRDSGEPPHKLLELCRDVIHYSVKTNHPRFFNQLYAGLDYYSLVARFMTEALNPSVYTYEVSP
  VFLLVEEAVLKKMIEFIGWKEGDGIFNPGGSVSNMYAMNLARYKYCPDIKEKGLSGSPRLILFTSAECHYSMKKA
  ASFLGIGTENVCFVETDGRGKMIPEELEKQVWQARKEGAAPFLVCATSGTTVLGAFDPLDEIADICERHSLWLHV
  DASWGGSALMSRKHRKLLHGIHRADSVAWNPHKMLMAGIQCCALLVKDKSDLLKKCYSAKASYLFQQDKFYDVSY
  DTGDKSIQCSRRPDAFKFWMTWKALGTLGLEERVNRALALSRYLVDEIKKREGFKLLMEPEYANICFWYIPPSLR
  EMEEGPEFWAKLNLVAPAIKERMMKKGSLMLGYQPHRGKVNFFRQVVISPQVSREDMDFLLDEIDLLGKDM

• Structural information:
  • Interpro: IPR039025  IPR002129  IPR015424  IPR015421  IPR021115  
  • Prosite: PS00392
  • STRING: ENSP00000282538
• Other Databases: GeneCards:  GADL1  Malacards:  GADL1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016831	carboxy-lyase activity	IEA	molecular function
GO:0019752	carboxylic acid metabolic process	IEA	biological process
GO:0030170	pyridoxal phosphate binding	IEA	molecular function
GO:0003824	catalytic activity	IEA	molecular function
GO:0016831	carboxy-lyase activity	IEA	molecular function
GO:0016829	lyase activity	IEA	molecular function
GO:0004068	aspartate 1-decarboxylase activity	IEA	molecular function
GO:0004782	sulfinoalanine decarboxylase activity	IEA	molecular function
GO:0000098	sulfur amino acid catabolic process	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0008652	cellular amino acid biosynthetic process	TAS	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00410	beta-Alanine metabolism
hsa00770	Pantothenate and CoA biosynthesis
hsa00430	Taurine and hypotaurine metabolism

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)