• Gene id: 339175

Gene Summary

• Gene Symbol: METTL2A   Gene   UCSC   Ensembl
• Aliases: METTL2
• Gene name: methyltransferase like 2A
• Alternate names: tRNA N(3)-methylcytidine methyltransferase METTL2A, methyltransferase-like protein 2A,
• Gene location: 17q23.2 (52927228: 53051697)     Exons: 18     NC_000001.11

Protein Summary

• Protein general information: Q96IZ6  
  • Name: tRNA N(3) methylcytidine methyltransferase METTL2A (EC 2.1.1. ) (Methyltransferase like protein 2A)
  • Length: 378  
  • Mass: 43537
• Sequence:

  MAGSYPEGAPAVLADKRQQFGSRFLRDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQVDYEINAH
  KYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENKSEVPECRNNEDGPGLIMEEQHKCSSKSLEH
  KTQTLPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTN
  SEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMMLLRDYGRYDMAQ
  LRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLS
  STS

• Structural information:
  • Interpro: IPR026113  IPR029063  
  • STRING: ENSP00000309610
• Other Databases: GeneCards:  METTL2A  Malacards:  METTL2A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0052735	tRNA (cytosine-3-)-methyltransferase activity	IBA	molecular function
GO:0030488	tRNA methylation	ISS	biological process
GO:0016427	tRNA (cytosine) methyltransferase activity	ISS	molecular function
GO:0008033	tRNA processing	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0032259	methylation	IEA	biological process
GO:0008168	methyltransferase activity	IEA	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)