• Gene id: 333926

Gene Summary

• Gene Symbol: PPM1J   Gene   UCSC   Ensembl
• Aliases: PP2CZ, PP2Czeta, PPP2CZ
• Gene name: protein phosphatase, Mg2+/Mn2+ dependent 1J
• Alternate names: protein phosphatase 1J, PP2C-zeta, protein phosphatase 1J (PP2C domain containing), protein phosphatase 2C isoform zeta, protein phosphatase 2C zeta, protein phosphatase 2a, catalytic subunit, zeta isoform,
• Gene location: 1p13.2 (112715327: 112709993)     Exons: 4     NC_000001.11
• Gene summary(Entrez): This gene encodes the serine/threonine protein phosphatase. The mouse homolog of this gene apparently belongs to the protein phosphatase 2C family of genes. The exact function of this gene is not yet known. [provided by RefSeq, Jul 2008]
• OMIM: 609957

Protein Summary

• Protein general information: Q5JR12  
  • Name: Protein phosphatase 1J (EC 3.1.3.16) (Protein phosphatase 2C isoform zeta) (PP2C zeta)
  • Length: 505  
  • Mass: 54834
• Sequence:

  MLNRVRSAVAHLVSSGGAPPPRPKSPDLPNAASAPPAAAPEAPRSPPAKAGSGSATPAKAVEARASFSRPTFLQL
  SPGGLRRADDHAGRAVQSPPDTGRRLPWSTGYAEVINAGKSRHNEDQACCEVVYVEGRRSVTGVPREPSRGQGLC
  FYYWGLFDGHAGGGAAEMASRLLHRHIREQLKDLVEILQDPSPPPLCLPTTPGTPDSSDPSHLLGPQSCWSSQKE
  VSHESLVVGAVENAFQLMDEQMARERRGHQVEGGCCALVVIYLLGKVYVANAGDSRAIIVRNGEIIPMSREFTPE
  TERQRLQLLGFLKPELLGSEFTHLEFPRRVLPKELGQRMLYRDQNMTGWAYKKIELEDLRFPLVCGEGKKARVMA
  TIGVTRGLGDHSLKVCSSTLPIKPFLSCFPEVRVYDLTQYEHCPDDVLVLGTDGLWDVTTDCEVAATVDRVLSAY
  EPNDHSRYTALAQALVLGARGTPRDRGWRLPNNKLGSGDDISVFVIPLGGPGSYS

• Structural information:
  • Protein Domains: (104..49-)
    (/note="PPM-type-phosphatase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01082"-)
  • Interpro: IPR015655  IPR036457  IPR001932  
  • Prosite: PS51746
  • CDD: cd00143
  • STRING: ENSP00000308926
• Other Databases: GeneCards:  PPM1J  Malacards:  PPM1J

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004722	protein serine/threonine phosphatase activity	IBA	molecular function
GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity	IBA	molecular function
GO:0005739	mitochondrion	IBA	cellular component
GO:1904184	positive regulation of pyruvate dehydrogenase activity	IBA	biological process
GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity	IBA	molecular function
GO:0006470	protein dephosphorylation	IEA	biological process
GO:0003824	catalytic activity	IEA	molecular function
GO:0004722	protein serine/threonine phosphatase activity	IEA	molecular function
GO:0004721	phosphoprotein phosphatase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0004721	phosphoprotein phosphatase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0004722	protein serine/threonine phosphatase activity	IEA	molecular function
GO:0006470	protein dephosphorylation	IEA	biological process

Diseases

Associated diseases	References
Hypospermatogenesis	MIK: 28361989
Non obstructive azoospermia	MIK: 24012201
Sertoli cell only syndrome	MIK: 23869807

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
24012201	Non obstructive azoospermia			31 (4 controls, 27 cases)	Male infertility	GSE45885 analyzed by GEO2R (cutoff 1.5 fold)
23869807	Non obstructive azoospermia, Sertoli cell only syndrome			20 (4 controls, 16 cases)	Male infertility	GSE45887 analyzed by GEO2R (cutoff 1.5 fold)
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray