|
Gene id |
3148 |
| Gene Summary Protein Summary Gene ontology Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
HMGB2 Gene UCSC Ensembl |
|
Aliases |
HMG2 |
|
Gene name |
high mobility group box 2 |
|
Alternate names |
high mobility group protein B2, HMG-2, high mobility group protein 2, high-mobility group (nonhistone chromosomal) protein 2, |
|
Gene location |
4q34.1 (173334357: 173331375) Exons: 5 NC_000002.12
|
|
Gene summary(Entrez) |
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated t
|
|
OMIM |
163906 |
Protein Summary
|
|
| GO accession | Term name | Evidence code | Go category |
|---|
|
|
| Associated diseases |
References |
| Oligozoospermia | GAD: 19369647 |
| Azoospermia | MIK: 19369647 |
| Fertility defects | MIK: 11262228 |
| Male factor infertility | MIK: 19369647 |
| Associated with spermatogenesis and epigenetic regulation | MIK: 21674046 |
| Reduced fertility, that correlates with Sertoli and germ cell degeneration in seminiferous tubules and immotile spermatozoa | MIK: 11262228 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 11262228 |
Reduced fe
rtility, t
hat correl
ates with
Sertoli an
d germ cel
l degenera
tion in se
miniferous
tubules a
nd immotil
e spermato
zoa
|
|
|
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
13 (5 controls,
8 cases)
|
Male infertility |
GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 21674046 |
Associated
with sper
matogenesi
s and epig
enetic reg
ulation
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
|