|
Gene id |
3065 |
| Gene Summary KEGG pathways Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
HDAC1 Gene UCSC Ensembl |
|
Aliases |
GON-10, HD1, KDAC1, RPD3, RPD3L1 |
|
Gene name |
histone deacetylase 1 |
|
Alternate names |
histone deacetylase 1, reduced potassium dependency, yeast homolog-like 1, |
|
Gene location |
1p35.2-p35.1 (32292082: 32333627) Exons: 14 NC_000001.11
|
|
Gene summary(Entrez) |
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the his
|
|
OMIM |
601241 |
|
|
|
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| Associated diseases |
References |
| Cancer | GAD: 19064572 |
| Huntington's disease | GAD: 19683447 |
| Endometriosis | INFBASE: 23080547 |
| Female infertility | INFBASE: 23690335 |
| Associated with spermatogenesis and epigenetic regulation | MIK: 21674046 |
| Involved in spermatogenesis | MIK: 26565999 |
| Low sperm motility | MIK: 21674046 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 26565999 |
Involved i
n spermato
genesis
|
|
|
|
Male infertility |
|
Show abstract |
| 21674046 |
Low sperm
motility
|
|
|
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
13 (5 controls,
8 cases)
|
Male infertility |
GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 21674046 |
Associated
with sper
matogenesi
s and epig
enetic reg
ulation
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
| 21674046 |
Low sperm
motility
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
|