• Gene id: 29122

Gene Summary

• Gene Symbol: PRSS50   Gene   UCSC   Ensembl
• Aliases: CT20, TSP50
• Gene name: serine protease 50
• Alternate names: probable threonine protease PRSS50, cancer/testis antigen 20, protease, serine 50, testes-specific protease 50, testicular tissue protein Li 210, testis-specific protease-like protein 50,
• Gene location: 3p21.31 (46717868: 46712116)     Exons: 6     NC_000003.12
• OMIM: 131240

Protein Summary

• Protein general information: Q9UI38  
  • Name: Probable threonine protease PRSS50 (EC 3.4.25. ) (Cancer/testis antigen 20) (Serine protease 50) (Testis specific protease like protein 50)
  • Length: 385  
  • Mass: 43088
  • Tissue specificity: Testis specific. Differentially expressed in some breast cancer tissues.
• Sequence:

  MGRWCQTVARGQRPRTSAPSRAGALLLLLLLLRSAGCWGAGEAPGALSTADPADQSVQCVPKATCPSSRPRLLWQ
  TPTTQTLPSTTMETQFPVSEGKVDPYRSCGFSYEQDPTLRDPEAVARRWPWMVSVRANGTHICAGTIIASQWVLT
  VAHCLIWRDVIYSVRVGSPWIDQMTQTASDVPVLQVIMHSRYRAQRFWSWVGQANDIGLLKLKQELKYSNYVRPI
  CLPGTDYVLKDHSRCTVTGWGLSKADGMWPQFRTIQEKEVIILNNKECDNFYHNFTKIPTLVQIIKSQMMCAEDT
  HREKFCYELTGEPLVCSMEGTWYLVGLVSWGAGCQKSEAPPIYLQVSSYQHWIWDCLNGQALALPAPSRTLLLAL
  PLPLSLLAAL

• Structural information:
  • Protein Domains: (93..35-)
    (/note="Peptidase-S1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00274"-)
  • Interpro: IPR009003  IPR001314  IPR001254  
  • Prosite: PS50240
  • CDD: cd00190
  • STRING: ENSP00000418875
• Other Databases: GeneCards:  PRSS50  Malacards:  PRSS50

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005783	endoplasmic reticulum	IBA	cellular component
GO:0004298	threonine-type endopeptidase activity	IBA	molecular function
GO:0006508	proteolysis	IDA	biological process
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0004298	threonine-type endopeptidase activity	IMP	molecular function
GO:0004252	serine-type endopeptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0006508	proteolysis	IEA	biological process
GO:0008233	peptidase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0004298	threonine-type endopeptidase activity	IEA	molecular function
GO:0005783	endoplasmic reticulum	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray