• Gene id: 29066

Gene Summary

• Gene Symbol: ZC3H7A   Gene   UCSC   Ensembl
• Aliases: HSPC055, ZC3H7, ZC3HDC7
• Gene name: zinc finger CCCH-type containing 7A
• Alternate names: zinc finger CCCH domain-containing protein 7A, zinc finger CCCH-type domain containing 7, zinc-finger protein AY163807,
• Gene location: 16p13.13 (11797257: 11750587)     Exons: 26     NC_000016.10

Protein Summary

• Protein general information: Q8IWR0  
  • Name: Zinc finger CCCH domain containing protein 7A
  • Length: 971  
  • Mass: 110538
• Sequence:

  MSNVSEERRKRQQNIKEGLQFIQSPLSYPGTQEQYAVYLRALVRNLFNEGNDVYREHDWNNSISQYTEALNIADY
  AKSEEILIPKEIIEKLYINRIACYSNMGFHDKVLEDCNIVLSLNASNCKALYRKSKALSDLGRYKKAYDAVAKCS
  LAVPQDEHVIKLTQELAQKLGFKIRKAYVRAELSLKSVPGDGATKALNHSVEDIEPDLLTPRQEAVPVVSLPAPS
  FSHEVGSELASVPVMPLTSILPLQVEESALPSAVLANGGKMPFTMPEAFLDDGDMVLGDELDDLLDSAPETNETV
  MPSALVRGPLQTASVSPSMPFSASLLGTLPIGARYAPPPSFSEFYPPLTSSLEDFCSSLNSFSMSESKRDLSTST
  SREGTPLNNSNSSLLLMNGPGSLFASENFLGISSQPRNDFGNFFGSAVTKPSSSVTPRHPLEGTHELRQACQICF
  VKSGPKLMDFTYHANIDHKCKKDILIGRIKNVEDKSWKKIRPRPTKTNYEGPYYICKDVAAEEECRYSGHCTFAY
  CQEEIDVWTLERKGAFSREAFFGGNGKINLTVFKLLQEHLGEFIFLCEKCFDHKPRMISKRNKDNSTACSHPVTK
  HEFEDNKCLVHILRETTVKYSKIRSFHGQCQLDLCRHEVRYGCLREDECFYAHSLVELKVWIMQNETGISHDAIA
  QESKRYWQNLEANVPGAQVLGNQIMPGFLNMKIKFVCAQCLRNGQVIEPDKNRKYCSAKARHSWTKDRRAMRVMS
  IERKKWMNIRPLPTKKQMPLQFDLCNHIASGKKCQYVGNCSFAHSPEEREVWTYMKENGIQDMEQFYELWLKSQK
  NEKSEDIASQSNKENGKQIHMPTDYAEVTVDFHCWMCGKNCNSEKQWQGHISSEKHKEKVFHTEDDQYCWQHRFP
  TGYFSICDRYMNGTCPEGNSCKFAHGNAELHEWEERRDALKMKLNKARKDHLIGPNDNDFGKYSFLFKDLN

• Structural information:
  • Interpro: IPR011990  IPR039691  IPR036236  IPR000571  IPR036855  
  • Prosite: PS50103 PS00028
  • PDB: 2D9M
  • PDBsum: 2D9M
  • STRING: ENSP00000379773
• Other Databases: GeneCards:  ZC3H7A  Malacards:  ZC3H7A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0035196	production of miRNAs involved in gene silencing by miRNA	IBA	biological process
GO:0035198	miRNA binding	IBA	molecular function
GO:0035198	miRNA binding	IDA	molecular function
GO:0035196	production of miRNAs involved in gene silencing by miRNA	IMP	biological process
GO:0010608	posttranscriptional regulation of gene expression	IMP	biological process
GO:0035198	miRNA binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0003723	RNA binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq