• Gene id: 286148

Gene Summary

• Gene Symbol: DPY19L4   Gene   UCSC   Ensembl
• Gene name: dpy-19 like 4
• Alternate names: probable C-mannosyltransferase DPY19L4, dpy-19-like protein 4, protein dpy-19 homolog 4,
• Gene location: 8q22.1 (94719707: 94793835)     Exons: 20     NC_000008.11
• OMIM: 613895

Protein Summary

• Protein general information: Q7Z388  
  • Name: Probable C mannosyltransferase DPY19L4 (EC 2.4.1. ) (Dpy 19 like protein 4) (Protein dpy 19 homolog 4)
  • Length: 723  
  • Mass: 83756
  • Tissue specificity: Widely expressed. {ECO
• Sequence:

  MAEEEGPPVELRQRKKPKSSENKESAKEEKISDIPIPERAPKHVLFQRFAKIFIGCLAAVTSGMMYALYLSAYHE
  RKFWFSNRQELEREITFQGDSAIYYSYYKDMLKAPSFERGVYELTHNNKTVSLKTINAVQQMSLYPELIASILYQ
  ATGSNEIIEPVYFYIGIVFGLQGIYVTALFVTSWLMSGTWLAGMLTVAWFVINRVDTTRIEYSIPLRENWALPYF
  ACQIAALTGYLKSNLNTYGERFCYLLMSASTYTFMMMWEYSHYLLFLQAISLFLLDTFSVEQSDKVYEVYKIYIF
  SLFLGYLLQFENPALLVSPLLSLVAALMLAKCLQLNVKKGSFVAKIIKVINFYLVCTLTITLNIIMKMFVPHKEN
  GHMLKFLEVKFGLNMTKNFTMNWLLCQESLQAPSQDFFLRLTQSSLLPFYILVLIICFLSMLQVIFRRINGKSLK
  ETVTLEDGRIGERPEIIYHVIHTILLGSLAMVIEGLKYIWIPYVCMLAAFGVCSPELWMTLFKWLRLRTVHPILL
  ALILSMAVPTIIGLSLWKEFFPRLMTELMELQEFYDPDTVELMTWIKRQAPVAAVFAGSPQLMGAIKLCTGWMVT
  SLPLYNDDDLLKRNENIYQIYSKRSAEDIYKILTSYKANYLIVEDAICNEVGPMRGCRVKDLLDIANGHMVCEEG
  DKLTYSKYGRFCHEVKINYSPYVNYFTRVYWNRSYFVYKINTVISFQS

• Structural information:
  • Interpro: IPR018732  IPR030040  
  • STRING: ENSP00000389630
• Other Databases: GeneCards:  DPY19L4  Malacards:  DPY19L4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000030	mannosyltransferase activity	IBA	molecular function
GO:0005637	nuclear inner membrane	IBA	cellular component
GO:0018406	protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan	IBA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016740	transferase activity	IEA	molecular function
GO:0016757	transferase activity, transferring glycosyl groups	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)