• Gene id: 285782

Gene Summary

• Gene Symbol: CAGE1   Gene   UCSC   Ensembl
• Aliases: CT3, CT95, CTAG3, bA69L16.7
• Gene name: cancer antigen 1
• Alternate names: cancer-associated gene 1 protein, cancer/testis antigen 3, cancer/testis antigen 95, cancer/testis antigen gene 1,
• Gene location: 6p24.3 (7389741: 7326658)     Exons: 15     NC_000006.12
• OMIM: 608304

Protein Summary

• Protein general information: Q8TC20  
  • Name: Cancer associated gene 1 protein (CAGE 1) (Cancer/testis antigen 3) (CT3)
  • Length: 777  
  • Mass: 90250
  • Tissue specificity: Testis-specific expression in normal tissues, but wide expression among cancer tissues and cell lines.
• Sequence:

  MNKDYQKFWSSPSDPVHFEVDTSHEKVESMSESDTMNVSNLSQGVMLSHSPICMETTGTTCDLPQNEIKNFEREN
  EYESTLCEDAYGTLDNLLNDNNIENYSTNALIQPVDTISISSLRQFETVCKFHWVEAFDDEMTEKPEFQSQVYNY
  AKDNNIKQDSFKEENPMETSVSANTDQLGNEYFRQPPPRSPPLIHCSGEMLKFTEKSLAKSIAKESALNPSQPPS
  FLCKTAVPSKEIQNYGEIPEMSVSYEKEVTAEGVERPEIVSTWSSAGISWRSEACRENCEMPDWEQSAESLQPVQ
  EDMALNEVLQKLKHTNRKQEVRIQELQCSNLYLEKRVKELQMKITKQQVFIDVINKLKENVEELIEDKYKIILEK
  NDTKKTLQNLEEVLANTQKHLQESRNDKEMLQLQFKKIKANYVCLQERYMTEMQQKNKSVSQYLEMDKTLSKKEE
  EVERLQQLKKELEKATASALDLLKREKEAQEQEFLSLQEEFQKLEKENLEERQKLKSRLEKLLTQVRNLQFMSEN
  ERTKNIKLQQQINEVKNENAKLKQQVARSEEQNYVPKFETAQLKDQLEEVLKSDITKDTKTTHSNLLPDCSPCEE
  RLNPADIKRASQLASKMHSLLALMVGLLTCQDIINSDAEHFKESEKVSDIMLQKLKSLHLKKKTLDKEVIDCDSD
  EAKSIRDVPTLLGAKLDKYHSLNEELDFLVTSYEEIIECADQRLAISHSQIAHLEERNKHLEDLIRKPREKARKP
  RSKSLENHPKSMTMMPALFKENRNDLD

• Structural information:
  • Interpro: IPR029381  
  • STRING: ENSP00000425493
• Other Databases: GeneCards:  CAGE1  Malacards:  CAGE1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq