• Gene id: 284525

Gene Summary

• Gene Symbol: SLC9C2   Gene   UCSC   Ensembl
• Aliases: SLC9A11
• Gene name: solute carrier family 9 member C2 (putative)
• Alternate names: sodium/hydrogen exchanger 11, NHE-11, Na(+)/H(+) exchanger 11, solute carrier family 9, solute carrier family 9, member 11,
• Gene location: 1q25.1 (173603071: 173500459)     Exons: 29     NC_000001.11
• OMIM: 0

Protein Summary

• Protein general information: Q5TAH2  
  • Name: Sodium/hydrogen exchanger 11 (Na(+)/H(+) exchanger 11) (NHE 11) (Solute carrier family 9 member 11) (Solute carrier family 9 member C2)
  • Length: 1124  
  • Mass: 129053
• Sequence:

  MSSYFWAQNESNRPDLLCGQPADYLVEEKHFTTLVCFIVVLGGLLKMCLKNCEVIVLTILSLSGFVIGHMAYNSV
  EVHQIVYPLLRTSSFSLYSYFSPLIIFMVALDVEFYTLKKMFWQVLLTGLISFSTASIIIGYVVIKFNKDSWDLQ
  SCLLFSITLGIIDPLRSVNSLKTIGISKIYIDLIRGESLIICSIASIFFGNFRGNRIHFSIFRDLHVGIELSYDI
  LGSIIFGYWCAKIIQCILADVFSNMLTNIILCFSMVYMTFYIVEFLGMSGTLALAAVGLNLDSLTFKPKIELVIT
  KFLRIFSSVYEHLIYAFFGIVIGCGELSHYEFHTIPFIFILFTTVNLVRLLTILLVSPILMHSNYEYNWRWGVVI
  TWSGIKGVFNLLWAPDVYNLAERKVEVPQMFILYVQVISLLTMGINSYVMTQSARKLDLCVLSLPRQMILQNATQ
  HIQEIVQNTITLFKTEKILTNVNWTLVEDKTRIEYIPFSHVSHNDMKTESTTDEALMEEARLHVAAIQMSSFEKQ
  RNNGILEIEAARILIGAAKCYYSIQGKFMSIYDVSTYMRTRSWLIKFKNVLTFLEYCIEKIHFIPPESNTFLTFI
  FHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVSALISINYYFMFLYVLESTLKIIILKRKYFQQCWNTLE
  FFILVIGIIDIFCVYFVKLRPDNLALIQLTVIMGYLRIIRFLPLFKIIVPILIRIADVQIKKRLSLMYSITKGYI
  KSQEDAKLLIKQIAVCESIYQKLCEILETNKQDAVKELVLMEHEGRDVVIALKTKQAIRNVIAKALKNLTFLCSR
  GIIDKHEVIEINKVLLKKLKALNNFPKAIPPPTPDIYLHNIIWLEGKDVLIDFFKERAKLACFDSGDTICKGGEM
  PQGIYLIISGMAILHSLSPTFGIESNQRCDRGSRDMFTEFCTTGDIIGELSCLLKREIEYTVICETSLQACFISL
  EDLYEGFDAFWPSLEYKIWLKLALSTAYQYFESSLIDEDLRFQNCVMFNQAYVETLSSYSDMIIDNMTMKFVIIV
  YGSVIDTKTEEPYFAPCIIPTTCEQVQGTSDLSKLLIIQASELTQRNSNTNVMASVNTVFEQPGKNINGRQKMS

• Structural information:
  • Interpro: IPR006153  IPR018422  IPR018490  IPR000595  IPR014710   IPR027359  
  • Prosite: PS50042
  • CDD: cd00038
  • STRING: ENSP00000356687
• Other Databases: GeneCards:  SLC9C2  Malacards:  SLC9C2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0098719	sodium ion import across plasma membrane	IBA	biological process
GO:0015385	sodium:proton antiporter activity	IBA	molecular function
GO:0071805	potassium ion transmembrane transport	IBA	biological process
GO:0051453	regulation of intracellular pH	IBA	biological process
GO:0015386	potassium:proton antiporter activity	IBA	molecular function
GO:0005886	plasma membrane	IBA	cellular component
GO:0006812	cation transport	IEA	biological process
GO:0015299	solute:proton antiporter activity	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0055085	transmembrane transport	IEA	biological process
GO:0015297	antiporter activity	IEA	molecular function
GO:0006814	sodium ion transport	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0006811	ion transport	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0098656	anion transmembrane transport	IEA	biological process
GO:1902600	proton transmembrane transport	IEA	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)