• Gene id: 284422

Gene Summary

• Gene Symbol: SMIM24   Gene   UCSC   Ensembl
• Aliases: C19orf77, HSPC323, MARDI
• Gene name: small integral membrane protein 24
• Alternate names: small integral membrane protein 24, MAP17-related dimer, transmembrane protein C19orf77, transmembrane protein HSPC323,
• Gene location: 19p13.3 (31489949: 31434647)     Exons: 22     NC_000022.11

Protein Summary

• Protein general information: O75264  
  • Name: Small integral membrane protein 24
  • Length: 130  
  • Mass: 14964
• Sequence:

  METLGALLVLEFLLLSPVEAQQATEHRLKPWLVGLAAVVGFLFIVYLVLLANRLWCSKARAEDEEETTFRMESNL
  YQDQSEDKREKKEAKEKEEKRKKEKKTAKEGESNLGLDLEEKEPGDHERAKSTVM

• Structural information:
  • Interpro: IPR031627  
  • STRING: ENSP00000215531
• Other Databases: GeneCards:  SMIM24  Malacards:  SMIM24

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0008150	biological_process	ND	biological process
GO:0003674	molecular_function	ND	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray