• Gene id: 279

Gene Summary

• Gene Symbol: AMY2A   Gene   UCSC   Ensembl
• Aliases: AMY2, PA
• Gene name: amylase, alpha 2A (pancreatic)
• Alternate names: pancreatic alpha-amylase, 1,4-alpha-D-glucan glucanohydrolase, glycogenase, pancreatic amylase alpha 2A,
• Gene location: 1p21.1 (103617331: 103625779)     Exons: 10     NC_000001.11
• Gene summary(Entrez): This gene encodes a member of the alpha-amylase family of proteins. Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, catalyzing the first step in digestion of dietary starch and glycogen. Thi
• OMIM: 104650

Protein Summary

• Protein general information: P04746  
  • Name: Pancreatic alpha amylase (PA) (EC 3.2.1.1) (1,4 alpha D glucan glucanohydrolase)
  • Length: 511  
  • Mass: 57,707
• Sequence:

  MKFFLLLFTIGFCWAQYSPNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPPNENVAIYNPFRPWWE
  RYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMCGNAVSAGTSSTCGSYFNPGSRDFPAVPYSGWD
  FNDGKCKTGSGDIENYNDATQVRDCRLTGLLDLALEKDYVRSKIAEYMNHLIDIGVAGFRLDASKHMWPGDIKAI
  LDKLHNLNSNWFPAGSKPFIYQEVIDLGGEPIKSSDYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWG
  FVPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWPRQFQNGNDVNDWVGP
  PNNNGVIKEVTINPDTTCGNDWVCEHRWRQIRNMVIFRNVVDGQPFTNWYDNGSNQVAFGRGNRGFIVFNNDDWS
  FSLTLQTGLPAGTYCDVISGDKINGNCTGIKIYVSDDGKAHFSISNSAEDPFIAIHAESKL

• Structural information:
  • Interpro: IPR006048  IPR031319  IPR006046  IPR006047  IPR013780   IPR017853  
  • PDB: 1B2Y 1BSI 1CPU 1HNY 1KB3 1KBB 1KBK 1KGU 1KGW 1KGX 1U2Y 1U30 1U33 1XCW 1XCX 1XD0 1XD1 1XGZ 1XH0 1XH1 1XH2 2CPU 2QMK 2QV4 3BAI 3BAJ 3BAK 3BAW 3BAX 3BAY 3CPU 3IJ7 3IJ8 3IJ9 3OLD 3OLE 3OLG 3OLI 4GQQ 4GQR 4W93 4X9Y 5E0F 5EMY 5KEZ 5TD4 5U3A
  • PDBsum: 1B2Y 1BSI 1CPU 1HNY 1KB3 1KBB 1KBK 1KGU 1KGW 1KGX 1U2Y 1U30 1U33 1XCW 1XCX 1XD0 1XD1 1XGZ 1XH0 1XH1 1XH2 2CPU 2QMK 2QV4 3BAI 3BAJ 3BAK 3BAW 3BAX 3BAY 3CPU 3IJ7 3IJ8 3IJ9 3OLD 3OLE 3OLG 3OLI 4GQQ 4GQR 4W93 4X9Y 5E0F 5EMY 5KEZ 5TD4 5U3A
  • STRING: ENSP00000397582
• Other Databases: GeneCards:  AMY2A  Malacards:  AMY2A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004556	alpha-amylase activity	IDA	molecular function
GO:0004556	alpha-amylase activity	TAS	molecular function
GO:0004556	alpha-amylase activity	TAS	molecular function
GO:0005509	calcium ion binding	IDA	molecular function
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005975	carbohydrate metabolic process	NAS	biological process
GO:0016052	carbohydrate catabolic process	IDA	biological process
GO:0031404	chloride ion binding	IDA	molecular function
GO:0044245	polysaccharide digestion	TAS	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0003824	catalytic activity	IEA	molecular function
GO:0004556	alpha-amylase activity	IEA	molecular function
GO:0004556	alpha-amylase activity	IDA	molecular function
GO:0004556	alpha-amylase activity	TAS	molecular function
GO:0004556	alpha-amylase activity	TAS	molecular function
GO:0004556	alpha-amylase activity	TAS	molecular function
GO:0005509	calcium ion binding	IDA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	TAS	cellular component
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0005975	carbohydrate metabolic process	NAS	biological process
GO:0008152	metabolic process	IEA	biological process
GO:0016052	carbohydrate catabolic process	IDA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA	molecular function
GO:0031404	chloride ion binding	IDA	molecular function
GO:0043169	cation binding	IEA	molecular function
GO:0044245	polysaccharide digestion	TAS	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0004556	alpha-amylase activity	IDA	molecular function
GO:0004556	alpha-amylase activity	TAS	molecular function
GO:0004556	alpha-amylase activity	TAS	molecular function
GO:0004556	alpha-amylase activity	TAS	molecular function
GO:0005509	calcium ion binding	IDA	molecular function
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	TAS	cellular component
GO:0005975	carbohydrate metabolic process	NAS	biological process
GO:0016052	carbohydrate catabolic process	IDA	biological process
GO:0031404	chloride ion binding	IDA	molecular function
GO:0044245	polysaccharide digestion	TAS	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa04972	Pancreatic secretion
hsa04973	Carbohydrate digestion and absorption

Diseases

Associated diseases	References
Parkinson disease	GAD: 15648851
Alzheimer's disease	GAD: 15648851
Endometriosis	INFBASE: 17609243
Fertilizing defects	MIK: 8359935
Sperm fertilization capacity	MIK: 17253186
Sperm fertilizing capacity	MIK: 17253186

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
8359935	Fertilization capacity			63 patients included in an in-vitro fertilization (IVF) programme	Male infertility
17253186	Sperm fertilizing capacity			170 (18 showed oligoasthenoteratospermia, 28 showed azoospermia, and 124 showed normozoospermia)	Male infertility