• Gene id: 27343

Gene Summary

• Gene Symbol: POLL   Gene   UCSC   Ensembl
• Aliases: BETAN, POLKAPPA
• Gene name: DNA polymerase lambda
• Alternate names: DNA polymerase lambda, DNA polymerase beta-2, DNA polymerase beta-N, DNA polymerase kappa, polymerase (DNA directed), lambda, polymerase (DNA) lambda,
• Gene location: 10q24.32 (101588318: 101578881)     Exons: 10     NC_000010.11
• Gene summary(Entrez): This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining
• OMIM: 193001

Protein Summary

• Protein general information: Q9UGP5  
  • Name: DNA polymerase lambda (Pol Lambda) (EC 2.7.7.7) (EC 4.2.99. ) (DNA polymerase beta 2) (Pol beta2) (DNA polymerase kappa)
  • Length: 575  
  • Mass: 63482
  • Tissue specificity: Expressed in a number of tissues. Abundant in testis.
• Sequence:

  MDPRGILKAFPKRQKIHADASSKVLAKIPRREEGEEAEEWLSSLRAHVVRTGIGRARAELFEKQIVQHGGQLCPA
  QGPGVTHIVVDEGMDYERALRLLRLPQLPPGAQLVKSAWLSLCLQERRLVDVAGFSIFIPSRYLDHPQPSKAEQD
  ASIPPGTHEALLQTALSPPPPPTRPVSPPQKAKEAPNTQAQPISDDEASDGEETQVSAADLEALISGHYPTSLEG
  DCEPSPAPAVLDKWVCAQPSSQKATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEAC
  SIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAI
  GLKHYSDFLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDS
  LRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGM
  SLSEHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW

• Structural information:
  • Protein Domains: (36..13-)
    (/note="BRCT-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00033"-)
  • Interpro: IPR001357  IPR036420  IPR002054  IPR019843  IPR010996   IPR028207  IPR018944  IPR027421  IPR037160  IPR022312  IPR002008  IPR029398  
  • Prosite: PS50172 PS00522
  • CDD: cd00141
  • PDB: 1NZP 1RZT 1XSL 1XSN 1XSP 2BCQ 2BCR 2BCS 2BCU 2BCV 2GWS 2JW5 2PFN 2PFO 2PFP 2PFQ 3C5F 3C5G 3HW8 3HWT 3HX0 3MDA 3MDC 3MGH 3MGI 3PML 3PMN 3PNC 3UPQ 3UQ0 3UQ2 4FO6 4K4G 4K4H 4K4I 4X5V 4XA5 4XQ8 4XRH 4XUS 5CA7 5CB1 5CHG 5CJ7 5CP2 5CR0 5CWR 5DDM 5DDY 5DKW 5III 5IIJ 5IIK 5IIL 5IIM 5IIN 5IIO 5W4G
  • PDBsum: 1NZP 1RZT 1XSL 1XSN 1XSP 2BCQ 2BCR 2BCS 2BCU 2BCV 2GWS 2JW5 2PFN 2PFO 2PFP 2PFQ 3C5F 3C5G 3HW8 3HWT 3HX0 3MDA 3MDC 3MGH 3MGI 3PML 3PMN 3PNC 3UPQ 3UQ0 3UQ2 4FO6 4K4G 4K4H 4K4I 4X5V 4XA5 4XQ8 4XRH 4XUS 5CA7 5CB1 5CHG 5CJ7 5CP2 5CR0 5CWR 5DDM 5DDY 5DKW 5III 5IIJ 5IIK 5IIL 5IIM 5IIN 5IIO 5W4G
  • DIP: 48999
  • STRING: ENSP00000359181
• Other Databases: GeneCards:  POLL  Malacards:  POLL

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006284	base-excision repair	IBA	biological process
GO:0006303	double-strand break repair via nonhomologous end joining	IBA	biological process
GO:0003887	DNA-directed DNA polymerase activity	IBA	molecular function
GO:0005634	nucleus	IBA	cellular component
GO:0051575	5'-deoxyribose-5-phosphate lyase activity	IDA	molecular function
GO:0006287	base-excision repair, gap-filling	IDA	biological process
GO:0071897	DNA biosynthetic process	IDA	biological process
GO:0003887	DNA-directed DNA polymerase activity	IDA	molecular function
GO:0006303	double-strand break repair via nonhomologous end joining	IMP	biological process
GO:0000724	double-strand break repair via homologous recombination	IMP	biological process
GO:0006281	DNA repair	IEA	biological process
GO:0016779	nucleotidyltransferase activity	IEA	molecular function
GO:0034061	DNA polymerase activity	IEA	molecular function
GO:0003677	DNA binding	IEA	molecular function
GO:0003887	DNA-directed DNA polymerase activity	IEA	molecular function
GO:0006281	DNA repair	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0006260	DNA replication	IEA	biological process
GO:0016829	lyase activity	IEA	molecular function
GO:0016779	nucleotidyltransferase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0071897	DNA biosynthetic process	IEA	biological process
GO:0003677	DNA binding	IEA	molecular function
GO:0006974	cellular response to DNA damage stimulus	IEA	biological process
GO:0003887	DNA-directed DNA polymerase activity	IEA	molecular function
GO:0003887	DNA-directed DNA polymerase activity	IEA	molecular function
GO:0003887	DNA-directed DNA polymerase activity	TAS	molecular function
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0006303	double-strand break repair via nonhomologous end joining	TAS	biological process
GO:0003887	DNA-directed DNA polymerase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0006289	nucleotide-excision repair	IDA	biological process
GO:0005634	nucleus	NAS	cellular component
GO:0003677	DNA binding	NAS	molecular function
GO:0016446	somatic hypermutation of immunoglobulin genes	NAS	biological process
GO:0003887	DNA-directed DNA polymerase activity	NAS	molecular function
GO:0006260	DNA replication	NAS	biological process

KEGG pathways

Pathway id	Pathway name
hsa03410	Base excision repair
hsa03450	Non-homologous end-joining

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881