• Gene id: 27106

Gene Summary

• Gene Symbol: ARRDC2   Gene   UCSC   Ensembl
• Aliases: CLONE24945, PP2703
• Gene name: arrestin domain containing 2
• Alternate names: arrestin domain-containing protein 2,
• Gene location: 19p13.11 (18001123: 18014101)     Exons: 9     NC_000019.10

Protein Summary

• Protein general information: Q8TBH0  
  • Name: Arrestin domain containing protein 2
  • Length: 407  
  • Mass: 44379
• Sequence:

  MLFDKVKAFSVQLDGATAGVEPVFSGGQAVAGRVLLELSSAARVGALRLRARGRAHVHWTESRSAGSSTAYTQSY
  SERVEVVSHRATLLAPDTGETTTLPPGRHEFLFSFQLPPTLVTSFEGKHGSVRYCIKATLHRPWVPARRARKVFT
  VIEPVDINTPALLAPQAGAREKVARSWYCNRGLVSLSAKIDRKGYTPGEVIPVFAEIDNGSTRPVLPRAAVVQTQ
  TFMARGARKQKRAVVASLAGEPVGPGQRALWQGRALRIPPVGPSILHCRVLHVDYALKVCVDIPGTSKLLLELPL
  VIGTIPLHPFGSRSSSVGSHASFLLDWRLGALPERPEAPPEYSEVVADTEEAALGQSPFPLPQDPDMSLEGPFFA
  YIQEFRYRPPPLYSEEDPNPLLGDMRPRCMTC

• Structural information:
  • Interpro: IPR011021  IPR014752  IPR011022  IPR014756  
  • STRING: ENSP00000222250
• Other Databases: GeneCards:  ARRDC2  Malacards:  ARRDC2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IBA	cellular component
GO:0005886	plasma membrane	IBA	cellular component
GO:0015031	protein transport	IBA	biological process
GO:0031410	cytoplasmic vesicle	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881