• Gene id: 2638

Gene Summary

• Gene Symbol: GC   Gene   UCSC   Ensembl
• Aliases: DBP, DBP-maf, DBP/GC, GRD3, Gc-MAF, GcMAF, HEL-S-51, VDB, VDBG, VDBP
• Gene name: GC, vitamin D binding protein
• Alternate names: vitamin D-binding protein, epididymis secretory protein Li 51, gc protein-derived macrophage activating factor, gc-globulin, group-specific component (vitamin D binding protein), vitamin D-binding alpha-globulin, vitamin D-binding protein-macrophage activ,
• Gene location: 4q13.3 (71805519: 71741692)     Exons: 15     NC_000004.12
• Gene summary(Entrez): The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports
• OMIM: 139200

Protein Summary

• Protein general information: P02774  
  • Name: Vitamin D binding protein (DBP) (VDB) (Gc protein derived macrophage activating factor) (Gc MAF) (GcMAF) (Gc globulin) (Group specific component) (Gc) (Vitamin D binding protein macrophage activating factor) (DBP maf)
  • Length: 474  
  • Mass: 52,964
• Sequence:

  MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACC
  AEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRK
  DPKEYANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAA
  YGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCC
  QEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVFLSKVLEPTLKSLGEC
  CDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKKKLAERLKAKLPDATPKELAKLVNKRSDFAS
  NCCSINSPPLYCDSEIDAELKNIL

• Structural information:
  • Protein Domains: Albumin (17-208)
    Albumin (209-394)
    Albumin (395-474)
  • Interpro: IPR000264  IPR020858  IPR020857  IPR014760  IPR000213   IPR015247  
  • Prosite: PS00212 PS51438
  • CDD: cd00015
  • PDB: 1J78 1J7E 1KW2 1KXP 1LOT 1MA9
  • PDBsum: 1J78 1J7E 1KW2 1KXP 1LOT 1MA9
  • DIP: 17038
  • STRING: ENSP00000421725
• Other Databases: GeneCards:  GC  Malacards:  GC

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003779	actin binding	IPI	molecular function
GO:0005499	vitamin D binding	TAS	molecular function
GO:0005576	extracellular region	NAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0007565	female pregnancy	IEA	biological process
GO:0007595	lactation	IEA	biological process
GO:0030424	axon	IEA	cellular component
GO:0031667	response to nutrient levels	IEA	biological process
GO:0032355	response to estradiol	IEA	biological process
GO:0042359	vitamin D metabolic process	TAS	biological process
GO:0043202	lysosomal lumen	TAS	cellular component
GO:0043202	lysosomal lumen	TAS	cellular component
GO:0048471	perinuclear region of cytoplasm	IEA	cellular component
GO:0051180	vitamin transport	IEA	biological process
GO:0051183	vitamin transporter activity	IEA	molecular function
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0072562	blood microparticle	IDA	cellular component
GO:1902118	calcidiol binding	IDA	molecular function
GO:0003779	actin binding	IEA	molecular function
GO:0003779	actin binding	IPI	molecular function
GO:0005499	vitamin D binding	IEA	molecular function
GO:0005499	vitamin D binding	IEA	molecular function
GO:0005499	vitamin D binding	IEA	molecular function
GO:0005499	vitamin D binding	TAS	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	NAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006810	transport	IEA	biological process
GO:0006810	transport	IEA	biological process
GO:0007565	female pregnancy	IEA	biological process
GO:0007595	lactation	IEA	biological process
GO:0030424	axon	IEA	cellular component
GO:0031667	response to nutrient levels	IEA	biological process
GO:0032355	response to estradiol	IEA	biological process
GO:0042359	vitamin D metabolic process	IEA	biological process
GO:0042359	vitamin D metabolic process	TAS	biological process
GO:0043202	lysosomal lumen	TAS	cellular component
GO:0043202	lysosomal lumen	TAS	cellular component
GO:0048471	perinuclear region of cytoplasm	IEA	cellular component
GO:0048545	response to steroid hormone	IEA	biological process
GO:0051180	vitamin transport	IEA	biological process
GO:0051180	vitamin transport	TAS	biological process
GO:0051183	vitamin transporter activity	IEA	molecular function
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0072562	blood microparticle	IDA	cellular component
GO:1902118	calcidiol binding	IDA	molecular function
GO:0003779	actin binding	IPI	molecular function
GO:0005499	vitamin D binding	TAS	molecular function
GO:0005576	extracellular region	NAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0042359	vitamin D metabolic process	TAS	biological process
GO:0043202	lysosomal lumen	TAS	cellular component
GO:0043202	lysosomal lumen	TAS	cellular component
GO:0051180	vitamin transport	TAS	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0072562	blood microparticle	IDA	cellular component
GO:1902118	calcidiol binding	IDA	molecular function

Diseases

Associated diseases	References
Cancer	GAD: 19692168
Cancer (bladder)	GAD: 19692168
Cancer (lung)	GAD: 18676680
Cancer (prostate)	GAD: 19255064
Cancer (breast)	GAD: 17244366
Cardiovascular disease	GAD: 18612209
Brain ischemia	GAD: 19131662
Coronary heart disease	GAD: 18612209
Hyperparathyroidism	GAD: 20424473
Graves disease	GAD: 12050214
Asthma	GAD: 16600026
Rheumatoid arthritis	GAD: 2786461
Multiple sclerosis	GAD: 12044990
Diabetes	GAD: 19479237
Osteoporosis	GAD: 15230135
Bone diseases	GAD: 15607028
Migraine disorder	GAD: 19559392
Alzheimer's disease	GAD: 19141999
Endometriosis	INFBASE: 15866120
Endometriosis	INFBASE: 20980430
Female infertility	INFBASE: 7818370
Asthenozoospermia	MIK: 20369545
Male factor infertility	MIK: 20231113
Asthenozoospermia	MIK: 20231113
Chronic obstructive pulmonary disease (COPD)	GAD: 20819447
Lung disease	GAD: 12947140
Calcinosis	GAD: 20847308
Asthenozoospermia	MIK: 20231113
Asthenozoospermia	MIK: 20369545

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
20369545	Asthenozoospermia			6 seminal plasma samples were collected by Percoll respectively from healthy fertile and asthenozoospermia volunteers	Male infertility	annexin VI isoform 2 isoform 1 of interleukin-6 receptor subunit beta precursor Mr 400 000 protein cytosolic dynein heavy chain alpha-actinin-4 receptor-type tyrosine-protein phosphatase eta precursor vitamin D-binding protein precursor protein S10
20231113	Asthenozoospermia			12 (6 healthy fertile men, 6 asthenozoospermia volunteers)	Male infertility	annexin VI isoform 2 isoform 1 of interleukin-6 receptor subunit beta precursor Mr 400 000 protein cytosolic dynein heavy chain alpha-actinin-4 receptor-type tyrosine-protein phosphatase eta precursor vitamin D-binding protein precursor protein S10