• Gene id: 262

Gene Summary

• Gene Symbol: AMD1   Gene   UCSC   Ensembl
• Aliases: ADOMETDC, AMD, SAMDC
• Gene name: adenosylmethionine decarboxylase 1
• Alternate names: S-adenosylmethionine decarboxylase proenzyme, S-adenosylmethionine decarboxylase 1,
• Gene location: 6q21 (103396504: 103389049)     Exons: 6     NC_000010.11
• Gene summary(Entrez): This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Multiple alternatively sp
• OMIM: 180980

Protein Summary

• Protein general information: P17707  
  • Name: S adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S adenosylmethionine decarboxylase alpha chain; S adenosylmethionine decarboxylase beta chain]
  • Length: 334  
  • Mass: 38340
• Sequence:

  MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSESSMFVSKR
  RFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMG
  RMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNP
  CGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQ
  KIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS

• Structural information:
  • Interpro: IPR001985  IPR016067  IPR018166  
  • Prosite: PS01336
  • PDB: 1I72 1I79 1I7B 1I7C 1I7M 1JEN 1JL0 1MSV 3DZ2 3DZ3 3DZ4 3DZ5 3DZ6 3DZ7 3EP3 3EP4 3EP5 3EP6 3EP7 3EP8 3EP9 3EPA 3EPB 3H0V 3H0W
  • PDBsum: 1I72 1I79 1I7B 1I7C 1I7M 1JEN 1JL0 1MSV 3DZ2 3DZ3 3DZ4 3DZ5 3DZ6 3DZ7 3EP3 3EP4 3EP5 3EP6 3EP7 3EP8 3EP9 3EPA 3EPB 3H0V 3H0W
  • DIP: 363
  • STRING: ENSP00000357880
• Other Databases: GeneCards:  AMD1  Malacards:  AMD1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0019810	putrescine binding	IBA	molecular function
GO:0006597	spermine biosynthetic process	IBA	biological process
GO:0008295	spermidine biosynthetic process	IBA	biological process
GO:0005829	cytosol	IBA	cellular component
GO:0004014	adenosylmethionine decarboxylase activity	IBA	molecular function
GO:0004014	adenosylmethionine decarboxylase activity	IEA	molecular function
GO:0008295	spermidine biosynthetic process	IEA	biological process
GO:0006597	spermine biosynthetic process	IEA	biological process
GO:0006596	polyamine biosynthetic process	IEA	biological process
GO:0016829	lyase activity	IEA	molecular function
GO:0016831	carboxy-lyase activity	IEA	molecular function
GO:0008295	spermidine biosynthetic process	IEA	biological process
GO:0004014	adenosylmethionine decarboxylase activity	IEA	molecular function
GO:0004014	adenosylmethionine decarboxylase activity	TAS	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0006595	polyamine metabolic process	TAS	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0008295	spermidine biosynthetic process	IEA	biological process
GO:0006595	polyamine metabolic process	IEA	biological process
GO:0005829	cytosol	IEA	cellular component
GO:0004014	adenosylmethionine decarboxylase activity	IEA	molecular function
GO:0046500	S-adenosylmethionine metabolic process	IEA	biological process
GO:0019810	putrescine binding	IEA	molecular function
GO:0006597	spermine biosynthetic process	IEA	biological process
GO:0006557	S-adenosylmethioninamine biosynthetic process	IEA	biological process
GO:0004014	adenosylmethionine decarboxylase activity	TAS	molecular function
GO:0004014	adenosylmethionine decarboxylase activity	TAS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00330	Arginine and proline metabolism
hsa00270	Cysteine and methionine metabolism

Diseases

Associated diseases	References
Prostate cancer	PMID:30397274
lung non-small cell carcinoma	PMID:30650190
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881