• Gene id: 26140

Gene Summary

• Gene Symbol: TTLL3   Gene   UCSC   Ensembl
• Aliases: HOTTL
• Gene name: tubulin tyrosine ligase like 3
• Alternate names: tubulin monoglycylase TTLL3, tubulin tyrosine ligase-like family, member 3, tubulin--tyrosine ligase-like protein 3,
• Gene location: 3p25.3 (9809914: 9836364)     Exons: 12     NC_000003.12
• OMIM: 613231

Protein Summary

• Protein general information: Q9Y4R7  
  • Name: Tubulin monoglycylase TTLL3 (EC 6.3.2. ) (HOTTL) (Tubulin tyrosine ligase like protein 3)
  • Length: 772  
  • Mass: 87414
• Sequence:

  MNRLRNAKIYVERAVKQKKIFTIQGCYPVIRCLLRRRGWVEKKMVHRSGPTLLPPQKDLDSSAMGDSDTTEDEDE
  DEDEEFQPSQLFDFDDLLKFDDLDGTHALMVGLCLNLRNLPWFDEVDANSFFPRCYCLGAEDDKKAFIEDFWLTA
  ARNVLKLVVKSEWKSYPIQAVEEEASGDKQPKKQEKNPVLVSPEFVDEALCACEEYLSNLAHMDIDKDLEAPLYL
  TPEGWSLFLQRYYQVVHEGAELRHLDTQVQRCEDILQQLQAVVPQIDMEGDRNIWIVKPGAKSRGRGIMCMDHLE
  EMLKLVNGNPVVMKDGKWVVQKYIERPLLIFGTKFDLRQWFLVTDWNPLTVWFYRDSYIRFSTQPFSLKNLDNSV
  HLCNNSIQKHLENSCHRHPLLPPDNMWSSQRFQAHLQEMGAPNAWSTIIVPGMKDAVIHALQTSQDTVQCRKASF
  ELYGADFVFGEDFQPWLIEINASPTMAPSTAVTARLCAGVQADTLRVVIDRMLDRNCDTGAFELIYKQPAVEVPQ
  YVGIRLLVEGFTIKKPMAMCHRRMGVRPAVPLLTQRGSGEARHHFPSLHTKAQLPSPHVLRHQGQVLRRQHSKLV
  GTKALSTTGKALRTLPTAKVFISLPPNLDFKVAPSILKPRKAPALLCLRGPQLEVPCCLCPLKSEQFLAPVGRSR
  PKANSRPDCDKPRAEACPMKRLSPLKPLPLVGTFQRRRGLGDMKLGKPLLRFPTALVLDPTPNKKKQVKYLGLDS
  IAVGGSRVDGARPCTPGSTARA

• Structural information:
  • Protein Domains: (151..51-)
    (/note="TTL-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00568"-)
  • Interpro: IPR004344  IPR027753  
  • Prosite: PS51221
  • STRING: ENSP00000392549
• Other Databases: GeneCards:  TTLL3  Malacards:  TTLL3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0070735	protein-glycine ligase activity	IDA	molecular function
GO:0018094	protein polyglycylation	IDA	biological process
GO:0070736	protein-glycine ligase activity, initiating	ISS	molecular function
GO:0060271	cilium assembly	ISS	biological process
GO:0015630	microtubule cytoskeleton	ISS	cellular component
GO:0005930	axoneme	ISS	cellular component
GO:0035082	axoneme assembly	ISS	biological process
GO:0005929	cilium	ISS	cellular component
GO:0006464	cellular protein modification process	IEA	biological process
GO:0018094	protein polyglycylation	IEA	biological process
GO:0070735	protein-glycine ligase activity	IEA	molecular function
GO:0042995	cell projection	IEA	cellular component
GO:0005524	ATP binding	IEA	molecular function
GO:0016874	ligase activity	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005929	cilium	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005874	microtubule	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0018094	protein polyglycylation	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005929	cilium	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq