• Gene id: 26133

Gene Summary

• Gene Symbol: TRPC4AP   Gene   UCSC   Ensembl
• Aliases: C20orf188, PPP1R158, TRRP4AP, TRUSS
• Gene name: transient receptor potential cation channel subfamily C member 4 associated protein
• Alternate names: short transient receptor potential channel 4-associated protein, TNF-receptor ubiquitous scaffolding/signaling protein, TRP4-associated protein, protein phosphatase 1, regulatory subunit 158, trpc4-associated protein, tumor necrosis factor receptor-associated ,
• Gene location: 20q11.22 (35092834: 35002403)     Exons: 22     NC_000020.11
• OMIM: 608430

Protein Summary

• Protein general information: Q8TEL6  
  • Name: Short transient receptor potential channel 4 associated protein (Trp4 associated protein) (Trpc4 associated protein) (Protein TAP1) (TNF receptor ubiquitous scaffolding/signaling protein) (Protein TRUSS)
  • Length: 797  
  • Mass: 90852
• Sequence:

  MAAAPVAAGSGAGRGRRSAATVAAWGGWGGRPRPGNILLQLRQGQLTGRGLVRAVQFTETFLTERDKQSKWSGIP
  QLLLKLHTTSHLHSDFVECQNILKEISPLLSMEAMAFVTEERKLTQETTYPNTYIFDLFGGVDLLVEILMRPTIS
  IRGQKLKISDEMSKDCLSILYNTCVCTEGVTKRLAEKNDFVIFLFTLMTSKKTFLQTATLIEDILGVKKEMIRLD
  EVPNLSSLVSNFDQQQLANFCRILAVTISEMDTGNDDKHTLLAKNAQQKKSLSLGPSAAEINQAALLSIPGFVER
  LCKLATRKVSESTGTASFLQELEEWYTWLDNALVLDALMRVANEESEHNQASIVFPPPGASEENGLPHTSARTQL
  PQSMKIMHEIMYKLEVLYVLCVLLMGRQRNQVHRMIAEFKLIPGLNNLFDKLIWRKHSASALVLHGHNQNCDCSP
  DITLKIQFLRLLQSFSDHHENKYLLLNNQELNELSAISLKANIPEVEAVLNTDRSLVCDGKRGLLTRLLQVMKKE
  PAESSFRFWQARAVESFLRGTTSYADQMFLLKRGLLEHILYCIVDSECKSRDVLQSYFDLLGELMKFNVDAFKRF
  NKYINTDAKFQVFLKQINSSLVDSNMLVRCVTLSLDRFENQVDMKVAEVLSECRLLAYISQVPTQMSFLFRLINI
  IHVQTLTQENVSCLNTSLVILMLARRKERLPLYLRLLQRMEHSKKYPGFLLNNFHNLLRFWQQHYLHKDKDSTCL
  ENSSCISFSYWKETVSILLNPDRQSPSALVSYIEEPYMDIDRDFTEE

• Structural information:
  • Interpro: IPR016024  IPR022162  
  • DIP: 42719
  • STRING: ENSP00000252015
• Other Databases: GeneCards:  TRPC4AP  Malacards:  TRPC4AP

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	IBA	cellular component
GO:0019902	phosphatase binding	IBA	molecular function
GO:0006511	ubiquitin-dependent protein catabolic process	IBA	biological process
GO:0006511	ubiquitin-dependent protein catabolic process	IDA	biological process
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	IDA	cellular component
GO:0019902	phosphatase binding	IDA	molecular function
GO:0016567	protein ubiquitination	IDA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0006511	ubiquitin-dependent protein catabolic process	IEA	biological process
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0070588	calcium ion transmembrane transport	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0048820	hair follicle maturation	IEA	biological process
GO:0016567	protein ubiquitination	IEA	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)