• Gene id: 26036

Gene Summary

• Gene Symbol: ZNF451   Gene   UCSC   Ensembl
• Aliases: COASTER, dJ417I1.1
• Gene name: zinc finger protein 451
• Alternate names: E3 SUMO-protein ligase ZNF451, E3 SUMO-protein transferase ZNF451, coactivator for steroid receptors,
• Gene location: 6p12.1 (57088969: 57170304)     Exons: 11     NC_000006.12
• OMIM: 615708

Protein Summary

• Protein general information: Q9Y4E5  
  • Name: E3 SUMO protein ligase ZNF451 (EC 2.3.2. ) (Coactivator for steroid receptors) (E3 SUMO protein transferase ZNF451) (Zinc finger protein 451)
  • Length: 1061  
  • Mass: 121484
• Sequence:

  MGDPGSEIIESVPPAGPEASESTTDENEDDIQFVSEGPLRPVLEYIDLVSSDDEEPSTSYTDENIKRKDHIDYQK
  DKVALTLARLARHVEVEKQQKEEKNRAFREKIDFQHAHGLQELEFIRGHSDTEAARLCVDQWLKMPGLKTGTINC
  GTKSSFRRGGHTWVSGKPILCPIMHCNKEFDNGHLLLGHLKRFDHSPCDPTITLHGPFFSSFACVVCYKKFVTQQ
  QYRDHLFDKEATDDGHNNNLLPQIIQCFACPNCFLLFSRKEECSKHMSGKNHFHQSFKLGDNKGIAHPISFPSFA
  KKLLISLCKDVPFQVKCVACHKTLRSHMELTAHFRVHCRNAGPVAVAEKSITQVAEKFILRGYCPDCNQVFVDET
  STQNHKQNSGHKVRVINSVEESVLLYCHSSEGNKDPSSDLHLLLDQSKFSSLKRTMSIKESSSLECIAIPKKKMN
  LKDKSHEGVACVQKEKSVVKTWFCECNQRFPSEDAVEKHVFSANTMGYKCVVCGKVCDDSGVIRLHMSRIHGGAH
  LNNFLFWCRTCKKELTRKDTIMAHVTEFHNGHRYFYEMDEVEGETLPSSSTTLDNLTANKPSSAITVIDHSPANS
  SPRGKWQCRICEDMFDSQEYVKQHCMSLASHKFHRYSCAHCRKPFHKIETLYRHCQDEHDNEIKIKYFCGLCDLI
  FNVEEAFLSHYEEHHSIDYVFVSEKTETSIKTEDDFPVIETSNQLTCGCRESYICKVNRKEDYSRCLQIMLDKGK
  LWFRCSLCSATAQNLTDMNTHIHQVHKEKSDEEEQQYVIKCGTCTKAFHDPESAQQHFHRKHCFLQKPSVAHFGS
  EKSNLYKFTASASHTERKLKQAINYSKSLDMEKGVENDLSYQNIEEEIVELPDLDYLRTMTHIVFVDFDNWSNFF
  GHLPGHLNQGTFIWGFQGGNTNWKPPLNCKIYNYLNRIGCFFLHPRCSKRKDAADFAICMHAGRLDEQLPKQIPF
  TILSGDQGFLELENQFKKTQRPAHILNPHHLEGDMMCALLNSISDTTKECDSDDNMGAKNTSIGEEFISTEDVEL
  EEAIRRSLEEM

• Structural information:
  • Interpro: IPR041192  IPR013087  
  • Prosite: PS00028 PS50157
  • PDB: 5D2M
  • PDBsum: 5D2M
  • DIP: 51264
  • STRING: ENSP00000359740
• Other Databases: GeneCards:  ZNF451  Malacards:  ZNF451

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0061665	SUMO ligase activity	IBA	molecular function
GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter	IBA	biological process
GO:0016925	protein sumoylation	IBA	biological process
GO:0010468	regulation of gene expression	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0003714	transcription corepressor activity	IBA	molecular function
GO:0061665	SUMO ligase activity	IDA	molecular function
GO:0016925	protein sumoylation	IDA	biological process
GO:0005634	nucleus	IDA	cellular component
GO:2000616	negative regulation of histone H3-K9 acetylation	IMP	biological process
GO:0003714	transcription corepressor activity	IMP	molecular function
GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter	IMP	biological process
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	IMP	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005654	nucleoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0016605	PML body	IEA	cellular component
GO:0016925	protein sumoylation	IEA	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)