• Gene id: 26018

Gene Summary

• Gene Symbol: LRIG1   Gene   UCSC   Ensembl
• Aliases: LIG-1, LIG1
• Gene name: leucine rich repeats and immunoglobulin like domains 1
• Alternate names: leucine-rich repeats and immunoglobulin-like domains protein 1, leucine-rich repeat protein LRIG1, ortholog of mouse integral membrane glycoprotein LIG-1,
• Gene location: 3p14.1 (66501120: 66378796)     Exons: 23     NC_000003.12
• OMIM: 300025

Protein Summary

• Protein general information: Q96JA1  
  • Name: Leucine rich repeats and immunoglobulin like domains protein 1 (LIG 1)
  • Length: 1093  
  • Mass: 119113
  • Tissue specificity: Widely expressed. {ECO
• Sequence:

  MARPVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNL
  SYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNN
  ITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRL
  IEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHR
  KGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTS
  GAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKW
  LPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSP
  MTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPS
  FTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQ
  NSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVV
  QNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEY
  SVTNTDETVVPPDVPSYLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAG
  SAYHKEPWKAMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPSAPNGPEPGGSDQEHS
  PHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGKGDSSWTLARLYHPDSTELQPASSLTSGSPERA
  EAQYLLVSNGHLPKACDASPESTPLTGQLPGKQRVPLLLAPKS

• Structural information:
  • Protein Domains: (35..6-)
    (/note="LRRNT-)
    (440..49-)
    (/note="LRRCT-)
    (495..59-)
    1 (/note="Ig-like-C2-type)
    (599..68-)
    2 (/note="Ig-like-C2-type)
    (693..77-)
    3" (/note="Ig-like-C2-type)
  • Interpro: IPR000483  IPR007110  IPR036179  IPR013783  IPR013098   IPR003599  IPR003598  IPR001611  IPR003591  IPR032675  IPR000372  
  • Prosite: PS50835 PS51450
  • PDB: 4U7L 4U7M
  • PDBsum: 4U7L 4U7M
  • STRING: ENSP00000273261
• Other Databases: GeneCards:  LRIG1  Malacards:  LRIG1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005615	extracellular space	IBA	cellular component
GO:0031012	extracellular matrix	IBA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0032474	otolith morphogenesis	IEA	biological process
GO:0060384	innervation	IEA	biological process
GO:0022405	hair cycle process	IEA	biological process
GO:0007605	sensory perception of sound	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component

Diseases

Associated diseases	References
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray