• Gene id: 25973

Gene Summary

• Gene Symbol: PARS2   Gene   UCSC   Ensembl
• Aliases: EIEE75, MT-PRORS, proRS
• Gene name: prolyl-tRNA synthetase 2, mitochondrial
• Alternate names: probable proline--tRNA ligase, mitochondrial, proline tRNA ligase 2, mitochondrial (putative), prolyl-tRNA synthetase 2, mitochondrial (putative),
• Gene location: 1p32.3 (54764522: 54756897)     Exons: 2     NC_000001.11
• Gene summary(Entrez): This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is lik
• OMIM: 612036

Protein Summary

• Protein general information: Q7L3T8  
  • Name: Probable proline tRNA ligase, mitochondrial (EC 6.1.1.15) (Prolyl tRNA synthetase) (ProRS)
  • Length: 475  
  • Mass: 53263
• Sequence:

  MEGLLTRCRALPALATCSRQLSGYVPCRFHHCAPRRGRRLLLSRVFQPQNLREDRVLSLQDKSDDLTCKSQRLML
  QVGLIYPASPGCYHLLPYTVRAMEKLVRVIDQEMQAIGGQKVNMPSLSPAELWQATNRWDLMGKELLRLRDRHGK
  EYCLGPTHEEAITALIASQKKLSYKQLPFLLYQVTRKFRDEPRPRFGLLRGREFYMKDMYTFDSSPEAAQQTYSL
  VCDAYCSLFNKLGLPFVKVQADVGTIGGTVSHEFQLPVDIGEDRLAICPRCSFSANMETLDLSQMNCPACQGPLT
  KTKGIEVGHTFYLGTKYSSIFNAQFTNVCGKPTLAEMGCYGLGVTRILAAAIEVLSTEDCVRWPSLLAPYQACLI
  PPKKGSKEQAASELIGQLYDHITEAVPQLHGEVLLDDRTHLTIGNRLKDANKFGYPFVIIAGKRALEDPAHFEVW
  CQNTGEVAFLTKDGVMDLLTPVQTV

• Structural information:
  • Interpro: IPR002314  IPR006195  IPR004154  IPR036621  IPR002316   IPR033730  
  • Prosite: PS50862
  • CDD: cd00779
  • STRING: ENSP00000360327
• Other Databases: GeneCards:  PARS2  Malacards:  PARS2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004827	proline-tRNA ligase activity	IBA	molecular function
GO:0006433	prolyl-tRNA aminoacylation	IBA	biological process
GO:0005739	mitochondrion	IBA	cellular component
GO:0004812	aminoacyl-tRNA ligase activity	IEA	molecular function
GO:0004827	proline-tRNA ligase activity	IEA	molecular function
GO:0006418	tRNA aminoacylation for protein translation	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0006433	prolyl-tRNA aminoacylation	IEA	biological process
GO:0006412	translation	IEA	biological process
GO:0004812	aminoacyl-tRNA ligase activity	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0016874	ligase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0004827	proline-tRNA ligase activity	IEA	molecular function
GO:0005759	mitochondrial matrix	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa00970	Aminoacyl-tRNA biosynthesis

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)