• Gene id: 25945

Gene Summary

• Gene Symbol: NECTIN3   Gene   UCSC   Ensembl
• Aliases: CD113, CDW113, NECTIN-3, PPR3, PRR3, PVRL3, PVRR3
• Gene name: nectin cell adhesion molecule 3
• Alternate names: nectin-3, nectin 3, poliovirus receptor-related 3, poliovirus receptor-related protein 3,
• Gene location: 3q13.13 (111071763: 111201443)     Exons: 14     NC_000003.12
• Gene summary(Entrez): This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regu
• OMIM: 607147

KEGG pathways

Pathway id	Pathway name
hsa04514	Cell adhesion molecules
hsa04520	Adherens junction

Diseases

Associated diseases	References
Endometriosis	INFBASE: 22926846
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Hypospermatogenesis	MIK: 28361989
Severe teratospermia, Male infertility	MIK: 28689229
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28689229	Severe teratospermia, Male infertility				Male infertility
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray