• Gene id: 25895

Gene Summary

• Gene Symbol: EEF1AKMT3   Gene   UCSC   Ensembl
• Aliases: FAM119B, METTL21B
• Gene name: EEF1A lysine methyltransferase 3
• Alternate names: EEF1A lysine methyltransferase 3, family with sequence similarity 119, member B, hepatocellular carcinoma-associated antigen 557a, hepatocellularcarcinoma-associated antigen HCA557a, methyltransferase like 21B, methyltransferase-like protein 21B, protein-lysine,
• Gene location: 12q14.1 (57772613: 57782540)     Exons: 4     NC_000012.12
• OMIM: 0

Protein Summary

• Protein general information: Q96AZ1  
  • Name: EEF1A lysine methyltransferase 3 (EC 2.1.1. ) (Hepatocellular carcinoma associated antigen 557a) (Methyltransferase like protein 21B) (Protein lysine methyltransferase METTL21B)
  • Length: 226  
  • Mass: 24911
• Sequence:

  MADPGPDPESESESVFPREVGLFADSYSEKSQFCFCGHVLTITQNFGSRLGVAARVWDAALSLCNYFESQNVDFR
  GKKVIELGAGTGIVGILAALQGGDVTITDLPLALEQIQGNVQANVPAGGQAQVRALSWGIDHHVFPANYDLVLGA
  DIVYLEPTFPLLLGTLQHLCRPHGTIYLASKMRKEHGTESFFQHLLPQHFQLELAQRDEDENVNIYRARHREPRP
  A

• Structural information:
  • Interpro: IPR019410  IPR029063  
  • PDB: 4QPN
  • PDBsum: 4QPN
  • STRING: ENSP00000300209
• Other Databases: GeneCards:  EEF1AKMT3  Malacards:  EEF1AKMT3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0018022	peptidyl-lysine methylation	IBA	biological process
GO:0008168	methyltransferase activity	IBA	molecular function
GO:0032259	methylation	IBA	biological process
GO:0016279	protein-lysine N-methyltransferase activity	IBA	molecular function
GO:0005829	cytosol	IBA	cellular component
GO:0016279	protein-lysine N-methyltransferase activity	IDA	molecular function
GO:0005813	centrosome	IDA	cellular component
GO:0008168	methyltransferase activity	IDA	molecular function
GO:0018022	peptidyl-lysine methylation	IDA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0032259	methylation	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0005622	intracellular	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0016279	protein-lysine N-methyltransferase activity	IEA	molecular function
GO:0018022	peptidyl-lysine methylation	IEA	biological process
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0005815	microtubule organizing center	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005813	centrosome	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0032991	protein-containing complex	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0031072	heat shock protein binding	IPI	molecular function
GO:0031072	heat shock protein binding	IPI	molecular function
GO:0031072	heat shock protein binding	IPI	molecular function
GO:0031072	heat shock protein binding	IPI	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)