• Gene id: 254552

Gene Summary

• Gene Symbol: NUDT8   Gene   UCSC   Ensembl
• Gene name: nudix hydrolase 8
• Alternate names: nucleoside diphosphate-linked moiety X motif 8, nucleoside diphosphate-linked moiety X motif 8, mitochondrial, nudix (nucleoside diphosphate linked moiety X)-type motif 8, nudix motif 8,
• Gene location: 11q13.2 (67629936: 67621420)     Exons: 5     NC_000011.10
• OMIM: 602052

Protein Summary

• Protein general information: Q8WV74  
  • Name: Nucleoside diphosphate linked moiety X motif 8 (Nudix motif 8) (EC 3.6.1. )
  • Length: 236  
  • Mass: 25370
• Sequence:

  MLPDCLSAEGELRCRRLLAGATARLRARPASAAVLVPLCSVRGVPALLYTLRSSRLTGRHKGDVSFPGGKCDPAD
  QDVVHTALRETREELGLAVPEEHVWGLLRPVYDPQKATVVPVLAGVGPLDPQSLRPNSEEVDEVFALPLAHLLQT
  QNQGYTHFCRGGHFRYTLPVFLHGPHRVWGLTAVITEFALQLLAPGTYQPRLAGLTCSGAEGLARPKQPLASPCQ
  ASSTPGLNKGL

• Structural information:
  • Protein Domains: (25..17-)
    (/note="Nudix-hydrolase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00794"-)
  • Interpro: IPR015797  IPR000086  
  • Prosite: PS51462
  • STRING: ENSP00000365883
• Other Databases: GeneCards:  NUDT8  Malacards:  NUDT8

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016787	hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881