• Gene id: 254240

Gene Summary

• Gene Symbol: BPIFC   Gene   UCSC   Ensembl
• Aliases: BPIL2
• Gene name: BPI fold containing family C
• Alternate names: BPI fold-containing family C protein, BPI-like 2, bactericidal/permeability-increasing protein-like 2,
• Gene location: 22q12.3 (32464464: 32413844)     Exons: 6     NC_000022.11
• OMIM: 614109

Protein Summary

• Protein general information: Q8NFQ6  
  • Name: BPI fold containing family C protein (Bactericidal/permeability increasing protein like 2) (BPI like 2)
  • Length: 507  
  • Mass: 56469
  • Tissue specificity: Detected in the basal layer of the epidermis from inflammatory skin from psoriasis patients, but not in normal skin.
• Sequence:

  MCTKTIPVLWGCFLLWNLYVSSSQTIYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDY
  VNYNFSNIKISAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLFQDTGGADLFLSGVYFTGIIILTRND
  FGHPTLKLQDCYAQLSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIASEVKALNANLSTLEVLTKIDN
  YTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPPFSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVF
  NVTLSTEEISNHFVQNSQGLGNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTV
  ETIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLANAKLQQGFPL
  SNPHKFLFVNSDIEVLEGFLLISTDLKYETSSKQQPSFHVWEGLNLISRQWRGKSAP

• Structural information:
  • Interpro: IPR017943  IPR030675  IPR032942  IPR032950  IPR001124   IPR017954  IPR017942  
  • Prosite: PS00400
  • STRING: ENSP00000380594
• Other Databases: GeneCards:  BPIFC  Malacards:  BPIFC

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005615	extracellular space	IBA	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0008289	lipid binding	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005543	phospholipid binding	NAS	molecular function
GO:0001530	lipopolysaccharide binding	NAS	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881