• Gene id: 254173

Gene Summary

• Gene Symbol: TTLL10   Gene   UCSC   Ensembl
• Aliases: TTLL5
• Gene name: tubulin tyrosine ligase like 10
• Alternate names: inactive polyglycylase TTLL10, tubulin tyrosine ligase-like family, member 10, tubulin tyrosine ligase-like family, member 5, tubulin--tyrosine ligase-like protein 10,
• Gene location: 1p36.33 (1173708: 1197935)     Exons: 21     NC_000001.11
• OMIM: 612039

Protein Summary

• Protein general information: Q6ZVT0  
  • Name: Inactive polyglycylase TTLL10 (Tubulin tyrosine ligase like protein 10)
  • Length: 673  
  • Mass: 75042
• Sequence:

  MDHSCTRFIHRRGPPTRTRAGFKRGKRPRIQQRPRARVSGTIPASRLHPAPASQPGPCPAPGHCPVGPAHERPMG
  SSQEEGLRCQPSQPDHDADGHCGPDLEGAERASATPGPPGLLNSHRPADSDDTNAAGPSAALLEGLLLGGGKPSP
  HSTRPGPFFYIGGSNGATIISSYCKSKGWQRIHDSRRDDYTLKWCEVKSRDSYGSFREGEQLLYQLPNNKLLTTK
  IGLLSTLRGRARAMSKASKVPGGVQARLEKDAAAPALEDLPWTSPGYLRPQRVLRMEEFFPETYRLDLKHEREAF
  FTLFDETQIWICKPTASNQGKGIFLLRNQEEVAALQAKTRSMEDDPIHHKTPFRGPQARVVQRYIQNPLLVDGRK
  FDVRSYLLIACTTPYMIFFGHGYARLTLSLYDPHSSDLGGHLTNQFMQKKSPLYMLLKEHTVWSMEHLNRYISDT
  FWKARGLAKDWVFTTLKKRMQQIMAHCFLAAKPKLDCKLGYFDLIGCDFLIDDNFKVWLLEMNSNPALHTNCEVL
  KEVIPGVVIETLDLVLETFRKSLRGQKMLPLLSQRRFVLLHNGEADPRPHLGGSCSLRRWPPLPTRQAKSSGPPM
  PHAPDQPGARRPAPPPLVPQRPRPPGPDLDSAHDGEPQAPGTEQSGTGNRHPAQEPSPGTAKEEREEPENARP

• Structural information:
  • Protein Domains: (155..55-)
    (/note="TTL-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00568"-)
  • Interpro: IPR004344  IPR027752  
  • Prosite: PS51221
  • STRING: ENSP00000368592
• Other Databases: GeneCards:  TTLL10  Malacards:  TTLL10

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0070735	protein-glycine ligase activity	IDA	NOT|molecular function
GO:0018094	protein polyglycylation	IDA	NOT|biological process
GO:0006464	cellular protein modification process	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0018094	protein polyglycylation	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq