• Gene id: 253152

Gene Summary

• Gene Symbol: EPHX4   Gene   UCSC   Ensembl
• Aliases: ABHD7, EH4, EPHXRP
• Gene name: epoxide hydrolase 4
• Alternate names: epoxide hydrolase 4, abhydrolase domain containing 7, abhydrolase domain-containing protein 7, epoxide hydrolase-related protein,
• Gene location: 1p22.1 (92029984: 92063537)     Exons: 7     NC_000001.11
• OMIM: 610534

Protein Summary

• Protein general information: Q8IUS5  
  • Name: Epoxide hydrolase 4 (EC 3.3. . ) (Abhydrolase domain containing protein 7) (Epoxide hydrolase related protein)
  • Length: 362  
  • Mass: 42324
• Sequence:

  MARLRDCLPRLMLTLRSLLFWSLVYCYCGLCASIHLLKLLWSLGKGPAQTFRRPAREHPPACLSDPSLGTHCYVR
  IKDSGLRFHYVAAGERGKPLMLLLHGFPEFWYSWRYQLREFKSEYRVVALDLRGYGETDAPIHRQNYKLDCLITD
  IKDILDSLGYSKCVLIGHDWGGMIAWLIAICYPEMVMKLIVINFPHPNVFTEYILRHPAQLLKSSYYYFFQIPWF
  PEFMFSINDFKVLKHLFTSHSTGIGRKGCQLTTEDLEAYIYVFSQPGALSGPINHYRNIFSCLPLKHHMVTTPTL
  LLWGENDAFMEVEMAEVTKIYVKNYFRLTILSEASHWLQQDQPDIVNKLIWTFLKEETRKKD

• Structural information:
  • Protein Domains: (94..21-)
    (/note="AB-hydrolase-1)
    (/evidence="ECO:0000255"-)
  • Interpro: IPR029058  IPR000073  IPR000639  
  • STRING: ENSP00000359410
• Other Databases: GeneCards:  EPHX4  Malacards:  EPHX4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004301	epoxide hydrolase activity	IBA	molecular function
GO:0016787	hydrolase activity	IBA	molecular function
GO:0097176	epoxide metabolic process	IBA	biological process
GO:0003824	catalytic activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0016020	membrane	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881