• Gene id: 23597

Gene Summary

• Gene Symbol: ACOT9   Gene   UCSC   Ensembl
• Aliases: ACATE2, CGI-16, MT-ACT48, MTACT48
• Gene name: acyl-CoA thioesterase 9
• Alternate names: acyl-coenzyme A thioesterase 9, mitochondrial, acyl-CoA thioester hydrolase 9, acyl-Coenzyme A thioesterase 2, mitochondrial, mitochondrial Acyl-CoA Thioesterase,
• Gene location: Xp22.11 (23743275: 23701054)     Exons: 16     NC_000023.11
• Gene summary(Entrez): The protein encoded by this gene is a mitochondrial acyl-CoA thioesterase of unknown function. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
• OMIM: 300862

Protein Summary

• Protein general information: Q9Y305  
  • Name: Acyl coenzyme A thioesterase 9, mitochondrial (Acyl CoA thioesterase 9) (EC 3.1.2. ) (Acyl CoA thioester hydrolase 9)
  • Length: 439  
  • Mass: 49902
• Sequence:

  MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQ
  DGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSPLSIVTALVD
  KIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQLHGDEFCPVLDATFVMVARDSENKGPAFVNPLIPESPE
  EEELFRQGELNKGRRIAFSSTSLLKMAPSAEERTTIHEMFLSTLDPKTISFRSRVLPSNAVWMENSKLKSLEICH
  PQERNIFNRIFGGFLMRKAYELAWATACSFGGSRPFVVAVDDIMFQKPVEVGSLLFLSSQVCFTQNNYIQVRVHS
  EVASLQEKQHTTTNVFHFTFMSEKEVPLVFPKTYGESMLYLDGQRHFNSMSGPATLRKDYLVEP

• Structural information:
  • Protein Domains: (84..20-)
    1 (/note="HotDog-ACOT-type)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01106-)
    (289..40-)
    2 (/note="HotDog-ACOT-type)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01106"-)
  • Interpro: IPR033120  IPR029069  
  • Prosite: PS51770
  • STRING: ENSP00000368605
• Other Databases: GeneCards:  ACOT9  Malacards:  ACOT9

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003986	acetyl-CoA hydrolase activity	ISS	molecular function
GO:0006637	acyl-CoA metabolic process	ISS	biological process
GO:0005739	mitochondrion	ISS	cellular component
GO:0047617	acyl-CoA hydrolase activity	IBA	molecular function
GO:0006637	acyl-CoA metabolic process	IBA	biological process
GO:0005739	mitochondrion	IBA	cellular component
GO:0016787	hydrolase activity	IEA	molecular function
GO:0052689	carboxylic ester hydrolase activity	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0005759	mitochondrial matrix	TAS	cellular component
GO:0006637	acyl-CoA metabolic process	TAS	biological process
GO:0005739	mitochondrion	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)