• Gene id: 23510

Gene Summary

• Gene Symbol: KCTD2   Gene   UCSC   Ensembl
• Gene name: potassium channel tetramerization domain containing 2
• Alternate names: BTB/POZ domain-containing protein KCTD2, potassium channel tetramerisation domain containing 2, potassium channel tetramerization domain-containing protein 2,
• Gene location: 17q25.1 (75032570: 75065885)     Exons: 10     NC_000017.11
• OMIM: 610530

Protein Summary

• Protein general information: Q14681  
  • Name: BTB/POZ domain containing protein KCTD2 (Potassium channel tetramerization domain containing protein 2)
  • Length: 263  
  • Mass: 28527
• Sequence:

  MAELQLDPAMAGLGGGGGSGVGDGGGPVRGPPSPRPAGPTPRGHGRPAAAVAQPLEPGPGPPERAGGGGAARWVR
  LNVGGTYFVTTRQTLGREPKSFLCRLCCQEDPELDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIITKELAEEG
  VLEEAEFYNIASLVRLVKERIRDNENRTSQGPVKHVYRVLQCQEEELTQMVSTMSDGWKFEQLISIGSSYNYGNE
  DQAEFLCVVSRELNNSTNGIVIEPSEKAKILQERGSRM

• Structural information:
  • Protein Domains: (72..17-)
    (/note="BTB"-)
  • Interpro: IPR000210  IPR011333  IPR003131  
  • STRING: ENSP00000312814
• Other Databases: GeneCards:  KCTD2  Malacards:  KCTD2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IBA	cellular component
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA	biological process
GO:0097602	cullin family protein binding	IBA	molecular function
GO:0031463	Cul3-RING ubiquitin ligase complex	IBA	cellular component
GO:0051260	protein homooligomerization	IEA	biological process
GO:0044877	protein-containing complex binding	IDA	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq