• Gene id: 23338

Gene Summary

• Gene Symbol: JADE2   Gene   UCSC   Ensembl
• Aliases: JADE-2, PHF15
• Gene name: jade family PHD finger 2
• Alternate names: E3 ubiquitin-protein ligase Jade-2, PHD finger protein 15, jade family PHD finger protein 2,
• Gene location: 5q31.1 (134524152: 134583227)     Exons: 16     NC_000005.10
• OMIM: 618366

Protein Summary

• Protein general information: Q9NQC1  
  • Name: E3 ubiquitin protein ligase Jade 2 (EC 2.3.2.27) (Jade family PHD finger protein 2) (PHD finger protein 15)
  • Length: 790  
  • Mass: 87466
• Sequence:

  MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITAMKIPDSYQLSPDDYY
  ILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSSTMLGEGSQPDWPGGSRYDLDEIDAYWLELI
  NSELKEMERPELDELTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVC
  VHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKIS
  HIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHGLEMRTILADNDEVKFKSFCQEHSDGGPRNEPTS
  EPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLAEALVDFIYQYWKLKRKANANQPLLTPKTDE
  VDNLAQQEQDVLYRRLKLFTHLRQDLERVRNLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRGLSTSFPI
  DGTFFNSWLAQSVQITAENMAMSEWPLNNGHREDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRL
  PAKKKPPPPPPQDGPGSRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPP
  LAPETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRLPGARPDAGMGPPSAVAERPKVSLHFDTETD
  GYFSDGEMSDSDVEAEDGGVQRGPREAGAEEVVRMGVLAS

• Structural information:
  • Interpro: IPR019542  IPR034732  IPR039549  IPR039548  IPR019786   IPR011011  IPR001965  IPR019787  IPR013083  
  • Prosite: PS51805 PS01359 PS50016
  • CDD: cd15705 cd15680
  • STRING: ENSP00000354425
• Other Databases: GeneCards:  JADE2  Malacards:  JADE2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0046872	metal ion binding	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005654	nucleoplasm	IDA	cellular component
GO:0016567	protein ubiquitination	IEA	biological process
GO:0043983	histone H4-K12 acetylation	IDA	biological process
GO:0043984	histone H4-K16 acetylation	IDA	NOT|biological process
GO:0043982	histone H4-K8 acetylation	IDA	biological process
GO:0043981	histone H4-K5 acetylation	IDA	biological process
GO:0043966	histone H3 acetylation	IDA	biological process
GO:0000123	histone acetyltransferase complex	IDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq