• Gene id: 23324

Gene Summary

• Gene Symbol: MAN2B2   Gene   UCSC   Ensembl
• Gene name: mannosidase alpha class 2B member 2
• Alternate names: epididymis-specific alpha-mannosidase, core-specific lysosomal alpha-1,6-Mannosidase, epididymis secretory sperm binding protein,
• Gene location: 4p16.1 (6575188: 6623361)     Exons: 20     NC_000004.12
• OMIM: 608441

Protein Summary

• Protein general information: Q9Y2E5  
  • Name: Epididymis specific alpha mannosidase (EC 3.2.1.24) (Mannosidase alpha class 2B member 2)
  • Length: 1009  
  • Mass: 113979
• Sequence:

  MGQLCWLPLLAPLLLLRPPGVQSAGPIRAFVVPHSHMDVGWVYTVQESMRAYAANVYTSVVEELARGQQRRFIAV
  EQEFFRLWWDGVASDQQKYQVRQLLEEGRLEFVIGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGIRPQFSWHV
  DPFGASATTPTLFALAGFNAHLGSRIDYDLKAAMQEARGLQFVWRGSPSLSERQEIFTHIMDQYSYCTPSHIPFS
  NRSGFYWNGVAVFPKPPQDGVYPNMSEPVTPANINLYAEALVANVKQRAAWFRTPHVLWPWGCDKQFFNASVQFA
  NMDPLLDHINSHAAELGVSVQYATLGDYFRALHALNVTWRVRDHHDFLPYSTEPFQAWTGFYTSRSSLKGLARRA
  SALLYAGESMFTRYLWPAPRGHLDPTWALQQLQQLRWAVSEVQHHDAITGTESPKVRDMYATHLASGMLGMRKLM
  ASIVLDELQPQAPMAASSDAGPAGHFASVYNPLAWTVTTIVTLTVGFPGVRVTDEAGHPVPSQIQNSTETPSAYD
  LLILTTIPGLSYRHYNIRPTAGAQEGTQEPAATVASTLQFGRRLRRRTSHAGRYLVPVANDCYIVLLDQDTNLMH
  SIWERQSNRTVRVTQEFLEYHVNGDVKQGPISDNYLFTPGKAAVPAWEAVEMEIVAGQLVTEIRQYFYRNMTAQN
  YTYAIRSRLTHVPQGHDGELLCHRIEQEYQAGPLELNREAVLRTSTNLNSQQVIYSDNNGYQMQRRPYVSYVNNS
  IARNYYPMVQSAFMEDGKSRLVLLSERAHGISSQGNGQVEVMLHRRLWNNFDWDLGYNLTLNDTSVVHPVLWLLL
  GSWSLTTALRQRSALALQHRPVVLFGDLAGTAPKLPGPQQQEAVTLPPNLHLQILSIPGWRYSSNHTEHSQNLRK
  GHRGEAQADLRRVLLRLYHLYEVGEDPVLSQPVTVNLEAVLQALGSVVAVEERSLTGTWDLSMLHRWSWRTGPGR
  HRGDTTSPSRPPGGPIITVHPKEIRTFFIHFQQQ

• Structural information:
  • Interpro: IPR011013  IPR041147  IPR011330  IPR011682  IPR015341   IPR037094  IPR000602  IPR027291  IPR028995  IPR013780  
  • STRING: ENSP00000285599
• Other Databases: GeneCards:  MAN2B2  Malacards:  MAN2B2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005774	vacuolar membrane	IBA	cellular component
GO:0004559	alpha-mannosidase activity	IBA	molecular function
GO:0006013	mannose metabolic process	IBA	biological process
GO:0006517	protein deglycosylation	IBA	biological process
GO:0004559	alpha-mannosidase activity	IEA	molecular function
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0006013	mannose metabolic process	IEA	biological process
GO:0003824	catalytic activity	IEA	molecular function
GO:0030246	carbohydrate binding	IEA	molecular function
GO:0008152	metabolic process	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA	molecular function
GO:0004559	alpha-mannosidase activity	IEA	molecular function
GO:0009313	oligosaccharide catabolic process	TAS	biological process
GO:0043202	lysosomal lumen	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa00511	Other glycan degradation

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq