• Gene id: 23309

Gene Summary

• Gene Symbol: SIN3B   Gene   UCSC   Ensembl
• Gene name: SIN3 transcription regulator family member B
• Alternate names: paired amphipathic helix protein Sin3b, SIN3 homolog B, transcriptional regulator, SIN3 transcription regulator homolog B, histone deacetylase complex subunit Sin3b, transcriptional corepressor Sin3b,
• Gene location: 19p13.11 (71886702: 72403144)     Exons: 43     NC_000006.12
• OMIM: 607777

Protein Summary

• Protein general information: O75182  
  • Name: Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b)
  • Length: 1162  
  • Mass: 133066
• Sequence:

  MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQ
  SIDTPGVIRRVSQLFHEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLTSQENSHNHGDGAEDFKQQVPYKEDK
  PQVPLESDSVEFNNAISYVNKIKTRFLDHPEIYRSFLEILHTYQKEQLNTRGRPFRGMSEEEVFTEVANLFRGQE
  DLLSEFGQFLPEAKRSLFTGNGPCEMHSVQKNEHDKTPEHSRKRSRPSLLRPVSAPAKKKMKLRGTKDLSIAAVG
  KYGTLQEFSFFDKVRRVLKSQEVYENFLRCIALFNQELVSGSELLQLVSPFLGKFPELFAQFKSFLGVKELSFAP
  PMSDRSGDGISREIDYASCKRIGSSYRALPKTYQQPKCSGRTAICKELDHWTLLQGSWTDDYCMSKFKNTCWIPG
  YSAGVLNDTWVSFPSWSEDSTFVSSKKTPYEEQLHRCEDERFELDVVLETNLATIRVLESVQKKLSRMAPEDQEK
  FRLDDSLGGTSEVIQRRAIYRIYGDKAPEIIESLKKNPVTAVPVVLKRLKAKEEEWREAQQGFNKIWREQYEKAY
  LKSLDHQAVNFKQNDTKALRSKSLLNEIESVYDEHQEQHSEGRSAPSSEPHLIFVYEDRQILEDAAALISYYVKR
  QPAIQKEDQGTIHQLLHQFVPSLFFSQQLDLGASEESADEDRDSPQGQTTDPSERKKPAPGPHSSPPEEKGAFGD
  APATEQPPLPPPAPHKPLDDVYSLFFANNNWYFFLRLHQTLCSRLLKIYRQAQKQLLEYRTEKEREKLLCEGRRE
  KGSDPAMELRLKQPSEVELEEYYPAFLDMVRSLLEGSIDPTQYEDTLREMFTIHAYVGFTMDKLVQNIARQLHHL
  VSDDVCLKVVELYLNEKKRGAAGGNLSSRCVRAARETSYQWKAERCMADENCFKVMFLQRKGQVIMTIELLDTEE
  AQTEDPVEVQHLARYVEQYVGTEGASSSPTEGFLLKPVFLQRNLKKFRRRWQSEQARALRGEARSSWKRLVGVES
  ACDVDCRFKLSTHKMVFIVNSEDYMYRRGTLCRAKQVQPLVLLRHHQHFEEWHSRWLEDNVTVEAASLVQDWLMG
  EEDEDMVPCKTLCETVHVHGLPVTRYRVQYSRRPASP

• Structural information:
  • Protein Domains: (37..10-)
    (/note="PAH-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00810-)
    (153..23-)
    (/note="PAH-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00810-)
    (292..36-)
    (/note="PAH-3)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00810"-)
  • Interpro: IPR013194  IPR003822  IPR036600  IPR039774  IPR031693  
  • Prosite: PS51477
  • STRING: ENSP00000369131
• Other Databases: GeneCards:  SIN3B  Malacards:  SIN3B

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000118	histone deacetylase complex	IBA	cellular component
GO:0004407	histone deacetylase activity	IBA	contributes to
GO:0016580	Sin3 complex	IBA	cellular component
GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	biological process
GO:0000785	chromatin	IBA	cellular component
GO:0003714	transcription corepressor activity	IBA	molecular function
GO:0016575	histone deacetylation	IBA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	ISS	cellular component
GO:0003714	transcription corepressor activity	IEA	molecular function
GO:0006355	regulation of transcription, DNA-templated	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0019216	regulation of lipid metabolic process	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0045892	negative regulation of transcription, DNA-templated	IEA	biological process
GO:0030849	autosome	IEA	cellular component
GO:0003682	chromatin binding	IEA	molecular function
GO:0001741	XY body	IEA	cellular component
GO:0000806	Y chromosome	IEA	cellular component
GO:0000805	X chromosome	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0003714	transcription corepressor activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq