• Gene id: 23306

Gene Summary

• Gene Symbol: NEMP1   Gene   UCSC   Ensembl
• Aliases: TMEM194, TMEM194A
• Gene name: nuclear envelope integral membrane protein 1
• Alternate names: nuclear envelope integral membrane protein 1, transmembrane protein 194, transmembrane protein 194A,
• Gene location: 12q13.3 (144284954: 144853033)     Exons: 85     NC_000006.12
• OMIM: 616496

Protein Summary

• Protein general information: O14524  
  • Name: Nuclear envelope integral membrane protein 1
  • Length: 444  
  • Mass: 50640
• Sequence:

  MAGGMKVAVSPAVGPGPWGSGVGGGGTVRLLLILSGCLVYGTAETDVNVVMLQESQVCEKRASQQFCYTNVLIPK
  WHDIWTRIQIRVNSSRLVRVTQVENEEKLKELEQFSIWNFFSSFLKEKLNDTYVNVGLYSTKTCLKVEIIEKDTK
  YSVIVIRRFDPKLFLVFLLGLMLFFCGDLLSRSQIFYYSTGMTVGIVASLLIIIFILSKFMPKKSPIYVILVGGW
  SFSLYLIQLVFKNLQEIWRCYWQYLLSYVLTVGFMSFAVCYKYGPLENERSINLLTWTLQLMGLCFMYSGIQIPH
  IALAIIIIALCTKNLEHPIQWLYITCRKVCKGAEKPVPPRLLTEEEYRIQGEVETRKALEELREFCNSPDCSAWK
  TVSRIQSPKRFADFVEGSSHLTPNEVSVHEQEYGLGSIIAQDEIYEEASSEEEDSYSRCPAITQNNFLT

• Structural information:
  • Interpro: IPR019358  
  • STRING: ENSP00000300128
• Other Databases: GeneCards:  NEMP1  Malacards:  NEMP1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005635	nuclear envelope	IBA	cellular component
GO:0005635	nuclear envelope	ISS	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005635	nuclear envelope	IEA	cellular component
GO:0005635	nuclear envelope	IEA	cellular component
GO:0005637	nuclear inner membrane	IEA	cellular component
GO:0003674	molecular_function	ND	molecular function
GO:0008150	biological_process	ND	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)