• Gene id: 23277

Gene Summary

• Gene Symbol: CLUH   Gene   UCSC   Ensembl
• Aliases: CLU1
• Gene name: clustered mitochondria homolog
• Alternate names: clustered mitochondria protein homolog, clustered mitochondria (cluA/CLU1) homolog,
• Gene location: 17p13.3 (2712019: 2689386)     Exons: 29     NC_000017.11
• OMIM: 601928

Protein Summary

• Protein general information: O75153  
  • Name: Clustered mitochondria protein homolog
  • Length: 1309  
  • Mass: 146670
• Sequence:

  MLLNGDCPESLKKEAAAAEPPRENGLDEAGPGDETTGQEVIVIQDTGFSVKILAPGIEPFSLQVSPQEMVQEIHQ
  VLMDREDTCHRTCFSLHLDGNVLDHFSELRSVEGLQEGSVLRVVEEPYTVREARIHVRHVRDLLKSLDPSDAFNG
  VDCNSLSFLSVFTDGDLGDSGKRKKGLEMDPIDCTPPEYILPGSRERPLCPLQPQNRDWKPLQCLKVLTMSGWNP
  PPGNRKMHGDLMYLFVITAEDRQVSITASTRGFYLNQSTAYHFNPKPASPRFLSHSLVELLNQISPTFKKNFAVL
  QKKRVQRHPFERIATPFQVYSWTAPQAEHAMDCVRAEDAYTSRLGYEEHIPGQTRDWNEELQTTRELPRKNLPER
  LLRERAIFKVHSDFTAAATRGAMAVIDGNVMAINPSEETKMQMFIWNNIFFSLGFDVRDHYKDFGGDVAAYVAPT
  NDLNGVRTYNAVDVEGLYTLGTVVVDYRGYRVTAQSIIPGILERDQEQSVIYGSIDFGKTVVSHPRYLELLERTS
  RPLKILRHQVLNDRDEEVELCSSVECKGIIGNDGRHYILDLLRTFPPDLNFLPVPGEELPEECARAGFPRAHRHK
  LCCLRQELVDAFVEHRYLLFMKLAALQLMQQNASQLETPSSLENGGPSSLESKSEDPPGQEAGSEEEGSSASGLA
  KVKELAETIAADDGTDPRSREVIRNACKAVGSISSTAFDIRFNPDIFSPGVRFPESCQDEVRDQKQLLKDAAAFL
  LSCQIPGLVKDCMEHAVLPVDGATLAEVMRQRGINMRYLGKVLELVLRSPARHQLDHVFKIGIGELITRSAKHIF
  KTYLQGVELSGLSAAISHFLNCFLSSYPNPVAHLPADELVSKKRNKRRKNRPPGAADNTAWAVMTPQELWKNICQ
  EAKNYFDFDLECETVDQAVETYGLQKITLLREISLKTGIQVLLKEYSFDSRHKPAFTEEDVLNIFPVVKHVNPKA
  SDAFHFFQSGQAKVQQGFLKEGCELINEALNLFNNVYGAMHVETCACLRLLARLHYIMGDYAEALSNQQKAVLMS
  ERVMGTEHPNTIQEYMHLALYCFASSQLSTALSLLYRARYLMLLVFGEDHPEMALLDNNIGLVLHGVMEYDLSLR
  FLENALAVSTKYHGPKALKVALSHHLVARVYESKAEFRSALQHEKEGYTIYKTQLGEDHEKTKESSEYLKCLTQQ
  AVALQRTMNEIYRNGSSANIPPLKFTAPSMASVLEQLNVINGILFIPLSQKDLENLKAEVARRHQLQEASRNRDR
  AEEPMATEPAPAGAPGDLGSQPPAAKDPSPSVQG

• Structural information:
  • Protein Domains: (335..57-)
    (/note="Clu-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01167"-)
  • Interpro: IPR027523  IPR033646  IPR025697  IPR028275  IPR011990  
  • Prosite: PS51823
  • CDD: cd15466
  • STRING: ENSP00000458986
• Other Databases: GeneCards:  CLUH  Malacards:  CLUH

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003729	mRNA binding	IBA	molecular function
GO:0005737	cytoplasm	IBA	cellular component
GO:0048312	intracellular distribution of mitochondria	IBA	biological process
GO:0003729	mRNA binding	IDA	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0007005	mitochondrion organization	IMP	biological process
GO:0048312	intracellular distribution of mitochondria	IMP	biological process
GO:0048312	intracellular distribution of mitochondria	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0007005	mitochondrion organization	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq