• Gene id: 23264

Gene Summary

• Gene Symbol: ZC3H7B   Gene   UCSC   Ensembl
• Aliases: ROXAN1, RoXaN
• Gene name: zinc finger CCCH-type containing 7B
• Alternate names: zinc finger CCCH domain-containing protein 7B, Rotavirus 'X' associated non-structural protein, rotavirus 'X'-associated non-structural protein, rotavirus X protein associated with NSP3, ubiquitous tetratricopeptide containing protein RoXaN,
• Gene location: 22q13.2 (41301524: 41360146)     Exons: 23     NC_000022.11
• Gene summary(Entrez): This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts with the rotavirus non-structural protein NSP3. [provided by RefSeq, Jul 2008]
• OMIM: 605118

Protein Summary

• Protein general information: Q9UGR2  
  • Name: Zinc finger CCCH domain containing protein 7B (Rotavirus 'X' associated non structural protein) (RoXaN)
  • Length: 977  
  • Mass: 109858
• Sequence:

  MERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVA
  LPRELLCKLHVNRAACYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHDE
  SVTQLGQELAQKLGLRVRKAYKRPQELETFSLLSNGTAAGVADQGTSNGLGSIDDIETDCYVDPRGSPALLPSTP
  TMPLFPHVLDLLAPLDSSRTLPSTDSLDDFSDGDVFGPELDTLLDSLSLVQGGLSGSGVPSELPQLIPVFPGGTP
  LLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLDPLDLLPYSETRLDALDSFGSTRGSLDKP
  DSFMEETNSQDHRPPSGAQKPAPSPEPCMPNTALLIKNPLAATHEFKQACQLCYPKTGPRAGDYTYREGLEHKCK
  RDILLGRLRSSEDQTWKRIRPRPTKTSFVGSYYLCKDMINKQDCKYGDNCTFAYHQEEIDVWTEERKGTLNRDLL
  FDPLGGVKRGSLTIAKLLKEHQGIFTFLCEICFDSKPRIISKGTKDSPSVCSNLAAKHSFYNNKCLVHIVRSTSL
  KYSKIRQFQEHFQFDVCRHEVRYGCLREDSCHFAHSFIELKVWLLQQYSGMTHEDIVQESKKYWQQMEAHAGKAS
  SSMGAPRTHGPSTFDLQMKFVCGQCWRNGQVVEPDKDLKYCSAKARHCWTKERRVLLVMSKAKRKWVSVRPLPSI
  RNFPQQYDLCIHAQNGRKCQYVGNCSFAHSPEERDMWTFMKENKILDMQQTYDMWLKKHNPGKPGEGTPISSREG
  EKQIQMPTDYADIMMGYHCWLCGKNSNSKKQWQQHIQSEKHKEKVFTSDSDASGWAFRFPMGEFRLCDRLQKGKA
  CPDGDKCRCAHGQEELNEWLDRREVLKQKLAKARKDMLLCPRDDDFGKYNFLLQEDGDLAGATPEAPAAAATATT
  GE

• Structural information:
  • Interpro: IPR013026  IPR011990  IPR019734  IPR039691  IPR036236   IPR000571  IPR036855  
  • Prosite: PS50005 PS50293 PS50103
  • STRING: ENSP00000345793
• Other Databases: GeneCards:  ZC3H7B  Malacards:  ZC3H7B

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0035198	miRNA binding	IBA	molecular function
GO:0035196	production of miRNAs involved in gene silencing by miRNA	IBA	biological process
GO:0035198	miRNA binding	IDA	molecular function
GO:0035196	production of miRNAs involved in gene silencing by miRNA	IMP	biological process
GO:0010608	posttranscriptional regulation of gene expression	IMP	biological process
GO:0035198	miRNA binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016032	viral process	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq