• Gene id: 23228

Gene Summary

• Gene Symbol: PLCL2   Gene   UCSC   Ensembl
• Aliases: PLCE2
• Gene name: phospholipase C like 2
• Alternate names: inactive phospholipase C-like protein 2, PLC-L(2), PLC-L2, PLC-epsilon-2, phospholipase C-L2, phospholipase C-epsilon-2,
• Gene location: 3p24.3 (16802690: 17090605)     Exons: 12     NC_000003.12
• OMIM: 610515

Protein Summary

• Protein general information: Q9UPR0  
  • Name: Inactive phospholipase C like protein 2 (PLC L(2)) (PLC L2) (Phospholipase C L2) (Phospholipase C epsilon 2) (PLC epsilon 2)
  • Length: 1127  
  • Mass: 125866
• Sequence:

  MAECGRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCSLGVSGDEARASPTRG
  PRGVALAPTPSAVVCTLPRESKPGGLPRRSSIIKDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELK
  KVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGEN
  YESLDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLN
  PGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH
  INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQF
  RGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSI
  KQQKVMVQHMKKLLGDKLYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKEN
  MEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARV
  FPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPG
  VSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELA
  MVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGK
  KSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPRFLGPDNTPL
  VVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKE
  RKLQKAVESFTWNITILKGQADLLKYAKNETLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDET
  GE

• Structural information:
  • Protein Domains: (141..25-)
    (/note="PH-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00145-)
    (426..57-)
    (/note="PI-PLC-X-box)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00270-)
    (618..73-)
    (/note="PI-PLC-Y-box)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU-)
  • Interpro: IPR000008  IPR035892  IPR011992  IPR011993  IPR001849   IPR001192  IPR017946  IPR015359  IPR028382  IPR000909  IPR001711  
  • Prosite: PS50004 PS50003 PS50007 PS50008
  • STRING: ENSP00000478458
• Other Databases: GeneCards:  PLCL2  Malacards:  PLCL2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0032959	inositol trisphosphate biosynthetic process	IBA	biological process
GO:0048015	phosphatidylinositol-mediated signaling	IBA	biological process
GO:0051209	release of sequestered calcium ion into cytosol	IBA	biological process
GO:0004435	phosphatidylinositol phospholipase C activity	IEA	molecular function
GO:0007165	signal transduction	IEA	biological process
GO:0032228	regulation of synaptic transmission, GABAergic	IEA	biological process
GO:0050811	GABA receptor binding	IEA	molecular function
GO:0070679	inositol 1,4,5 trisphosphate binding	IEA	molecular function
GO:0006629	lipid metabolic process	IEA	biological process
GO:0008081	phosphoric diester hydrolase activity	IEA	molecular function
GO:0035556	intracellular signal transduction	IEA	biological process
GO:0007165	signal transduction	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0050811	GABA receptor binding	IDA	molecular function
GO:1900122	positive regulation of receptor binding	IEA	biological process
GO:0033135	regulation of peptidyl-serine phosphorylation	IEA	biological process
GO:0032228	regulation of synaptic transmission, GABAergic	IEA	biological process
GO:0120163	negative regulation of cold-induced thermogenesis	IEA	biological process
GO:0050859	negative regulation of B cell receptor signaling pathway	IEA	biological process
GO:0007214	gamma-aminobutyric acid signaling pathway	IEA	biological process
GO:0002337	B-1a B cell differentiation	IEA	biological process
GO:0002322	B cell proliferation involved in immune response	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0120163	negative regulation of cold-induced thermogenesis	ISS	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq